鼻渊息胶囊对小鼠急性鼻炎的作用

目的:观察鼻渊息胶囊对急性鼻炎小鼠的疗效及其抗炎、镇痛作用。方法:采用二甲苯鼻腔滴入方法制备急性鼻炎小鼠模型;采用二甲苯致小鼠耳廓肿胀、醋酸致小鼠腹腔毛细血管通透性增高,大鼠棉球肉芽肿实验;采用小鼠醋酸扭体实验。结果:鼻渊息胶囊能够明显减少急性鼻炎小鼠鼻腔黏膜的炎细胞浸润,减少分泌物及渗出物;对二甲苯所致小鼠耳肿、醋酸致小鼠腹腔毛细血管通透性增高、大鼠棉球致肉芽组织增生均有显著的抑制作用;对醋酸引起的小鼠扭体次数有明显减少。结论:鼻渊息胶囊有明显的抗炎,镇痛作用,是治疗鼻炎的有效药物。

Effects of Biyuanxi Capsule on Acute Rhinitis Rat Models

Objective: To investigate the effects of Biyuanxi capsule on acute rhinitis, anti-inflammatory function and relieve pain function. Method: By means of mice acute rhinitis induced by xylene;by means of the swelling of mice ears induced by xylene, swelling of granulation in cotton ball and the penetrating of blood capillary in abdominal cavity;by means of mice twisting bodies caused by acetic acid. Result: BiYuanxi capsule has the favorable treatment for the mice model of acute rhinitis. BiYuanxi capsule can significantly inhibit swelling of mice ears induced by xylene,swelling of the penetration of blood capillary in abdominal cavity and granulation in cotton ball. BiYuanxi capsule can enhance the threshold of pain of mice pain caused by acetic acid. Conclusion: Biyuanxi capsule has the significantly effects of anti-inflammatory and analgesic effects.Biyuanxi capsule has the favorable treatment for acute rhinitis