乙肝转阴颗粒对D-半乳糖胺诱导小鼠 急性肝损伤的保护作用

目的:研究乙肝转阴颗粒(YGZYDG)对D-半乳糖胺(D-GalN)所致小鼠急性肝损伤的保护作用,并探讨其作用机制。方法:观测YGZYDG(1.68,0.84,0.42 g·kg-1)连续ig 7 d,对ip D-GalN(0.8 g·kg-1)致急性肝损伤模型小鼠血清门冬氨酸氨基转移酶(AST),丙氨酸氨基转移酶(ALT),碱性磷酸酶(AKP)活性,血清白蛋白(Alb)含量,总抗氧化能力(T-AOC)以及肝组织丙二醛(MDA)含量,超氧化物歧化酶(SOD)活性的影响。结果:与模型组比较,YGZYDG能降低血清AST,ALT和AKP的活性及肝组织MDA含量;提高血清Alb含量,T-AOC能力和肝组织SOD活性(P<0.01或P<0.05);能够减轻肝细胞损伤程度。结论:YGZYDG对D-半乳糖胺所致的急性肝损伤具有保护作用,其机制可能与其抗氧自由基、抑制脂质过氧化作用有关。

Protection of Yigan Zhuanyin Granules on Acute Liver Injuries Induced by D-galactosamine in Mice

Objective: To study the effect of Yigan Zhuanyin granules(ZGZYG)on acute liver injuries induced by D-galactosamine(D-GalN)in mice and its mechanism. Method :After oral administration of YGZYG(1.68,0.84,0.42 g ·kg^-1)for seven days, the mice were abdominally administrated D-GalN(0.8 g ·kg^-1)to induce liver injury. The activities of AST,ALT and ALP,the content of Alb,the ability of T-AOC in serum,the content of MDA,and the activity of SOD in liver tissue were investigated. Result: Compared with model group,the activities of AST,ALT and AKP,and the content of MDA in the treatment groups were decreased;while the content of Alb,the ability of T-AOC,and the activity of SOD were increased(P<0.01 or P<0.05). The degree of hepatic injury was lessened. Conclusion: YGZYG has protective effect on acute liver injury induced chemically. The mechanism may be related to attenuating free radical and inhibiting the effect on lipid peroxidation.