胃癌患者血清CEA、CA19—9及CA72—4联检的临床价值探讨

目的：探讨血清CEA、CA19—9及CA72—4联检在胃癌诊断、病情监测及疗效观察中的价值。方法：采用电化学发光技术检测36例正常对照组、42例良性胃病、55例胃癌患者血清CEA、CA19—9、CA72—4的含量，并对胃癌患者进行治疗前后三种肿瘤标志物的含量变化监测随防。结果：胃癌患者血清CEA、CA19—9、CA72—4的阳性率明显高于正常对照组及良性胃病组，差异有显著性（P〈0．01）。胃癌患者治疗后三种肿瘤标志物含量及阳性率较治疗前有明显下降，差异有显著性（P〈0．01）。三者联检的敏感性、准确性均显著提高（P〈0．01）。结论：血清CEA、CA19-9、CA72—4联检有助于提高胃癌诊断的敏感性、同时对疗效观察及术后监测有重要意义。

Clinical Significance of Determination of Changes of Serum CEA, CA19-9 and CA72-4 Levels After Operation Patients with Gastric Cancer

Objective To study the significance of changes of combined detection of serum CEA,CA19-9 and CA72-4 levels after operation for diagnosis and assessment of therapeutic effectiveness in patients with gastric cancer.Methods Serun levels of CEA,CA19-9 and CA72-4 were measurrd with electrochem ilum inescence assay in 36 controls,42 patients with benign gastric disorders and 55 patients with gastric cancer(both before and affter operation).Results The levels of these three markers in patients with gastric cancer before operation were significantly higher than those in controls and patients with benign gastric disorders(P<0.01).The serum levels significantly decreased after treatment(P<0.01) approching those in controls.Both sensitivity and specificity of detection were improved with combined detection of CEA,CA19-9 and CA72-4(P<0.01).Conclusion The combined detection of CEA,CA19-9 and CA72-4 can significantly improve the sensitivity and specificity of diagnosis of gastric cancer and also has a notable value in assessing the therapeutic effectiveness.