| 肾小球滤过率评估方程在中青年慢性肾脏病人中的适用性 |
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| 引用本文： | 翁敏,毕丹青,韩晓玲,白云凯,曹剑鸣. 肾小球滤过率评估方程在中青年慢性肾脏病人中的适用性[J]. 云南医药, 2008, 29(6) |
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| 作者姓名： | 翁敏 毕丹青 韩晓玲 白云凯 曹剑鸣 |
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| 作者单位： | [1]昆明医学院第一附属医院肾内科,云南昆明650032 [2]昆明医学院第一附属医院核医学科,云南昆明650032 |
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| 摘 要： | 目的探讨肾小球滤过率（GFR）评估方程在我国中青年慢性肾脏病（CKD）患者中的适用性。方法选择102例中青年慢性肾脏病患者，将Cockcroft—Gauh方程、MDRD7方程、简化MDRD方程计算的GFR值用体表面积（BSA）标准化与BSA标准化的^99mTc—DTPA测得的GFR在不同CKD分期进行比较。结果方程计算的GFR（cGFR、7GFR、aGFR）与^99mTc—GFR（sGFR）均具有显著的相关性，相关性较好的依次为MDRD7、简化MDRD和Cockcroft—Gauh方程；在Roc曲线下的平均面积上述三个公式分别是0．86、0．83和0．80。cGFR、7GFR、aGFR与^99mTc—GFR差异均有显著意义（P〈0．01）。结论上述方程用于我国CKD患者时，应对其进行适当修正。
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| 关 键 词： | 肾小球滤过率 MDRD方程 Cockcroft—Gauh方程 |
Evaluation on glomerular filtration rate estimated with three equations in Chinese young and middle-aged patients with chronic kidney disease. |
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| WENG Min,BI Dan-qing,HAN Xiao-ling,et al.. Evaluation on glomerular filtration rate estimated with three equations in Chinese young and middle-aged patients with chronic kidney disease.[J]. Medicine and Pharmacy of Yunnan, 2008, 29(6) |
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| Authors: | WENG Min BI Dan-qing HAN Xiao-ling et al. |
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| Affiliation: | WENG Min,BI Dan-qing,HAN Xiao-ling,et al.(Department of Nephrology,the First Affiliated Hospital of Kunming Medical College,Kunming 650032,China) |
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| Abstract: | Objective To evaluate the applicability of three equations of glomerular filtration rate in Chinese young and middle-aged patients with chronic kidney disease(CKD).Methods CKD were diagnosed according to K/DOQI guideline.102 patients with CKD were selected.Glomerular filtration rates(GFR) estimated with MDRD seven equation,abbreviated MDRD equation,and Cockcroft-Gault(CG) equation were compared with 99mTc-DTPA plasma clearance(sGFR) in different stages of CKD.The GFRs were standarded by body surface area.Re... |
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| Keywords: | Glomerular filtration rate MDRD equation Cockcroft-Gault equation |
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