| 黄葵胶囊治疗IgA肾病湿热证蛋白尿的临床观察 |
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| 引用本文： | 王丽萍,张勇,陈建,庄永泽,杜建.黄葵胶囊治疗IgA肾病湿热证蛋白尿的临床观察[J].中成药,2010,32(1):18-21. |
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| 作者姓名： | 王丽萍 张勇 陈建 庄永泽 杜建 |
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| 作者单位： | 福建中医学院;南京军区福州总医院肾内科;福建医科大学福总临床医学院; |
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| 基金项目： | 福建省中西医结合老年性疾病重点实验室开放课题(2008J1004-58); 陈可冀中西医结合发展基金(CKJ2008095) |
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| 摘 要： | 目的:观察黄葵胶囊(黄蜀葵花)治疗IgA肾病湿热证的临床疗效。方法:将64例IgA肾病湿热证患者随机分为治疗组和对照组,治疗组32例给予黄葵胶囊4粒,3次/日治疗,对照组采用常规西药福辛普利(蒙诺)10mg,1次/日治疗,疗程12周,观察两组治疗前后中医湿热证证候积分、24h尿蛋白定量、血肌酐、尿素氮的变化及肝功能、电解质、不良事件等安全性指标。结果:两组病人临床资料无统计学差异。治疗12周后对照组和治疗组的24h尿蛋白分别较治疗前降低(0.49±0.78)g/24h和(0.4±0.76)g/24h(P<0.05),两组差异无显著性(P>0.05);对照组和治疗组中医湿热证证候积分分别下降(0.88±1.43)和(1.94±1.63)(P<0.05),两组差异有显著性(P<0.05)。治疗组西医总有效率为53.1%,对照组为65.6%(P>0.05);治疗组中医总有效率84.4%,对照组为50.0%,两组比较差异有显著性(P<0.01)。与治疗前相比,两组的血肌酐、尿素氮均无明显变化(P>0.05)。治疗12周中两组不良事件发生率差异无显著性,且均未发生严重不良事件。结论:黄葵胶囊可以减少IgA肾病湿热证患者...
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| 关 键 词： | IgA肾病 湿热证 黄葵胶囊 福辛普利 |
Therapeutic effect of Huangkui Capsule on IgA nephropathy with damp-heat syndrome |
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| WANG Li-ping ,ZHANG Yong,CHEN Jian,ZHUANG Yong-ze,DU Jian.Therapeutic effect of Huangkui Capsule on IgA nephropathy with damp-heat syndrome[J].Chinese Traditional Patent Medicine,2010,32(1):18-21. |
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| Authors: | WANG Li-ping ZHANG Yong CHEN Jian ZHUANG Yong-ze DU Jian |
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| Institution: | WANG Li-ping 1,2,ZHANG Yong2,CHEN Jian2,ZHUANG Yong-ze2,DU Jian1(1.Fujian College of TCM,Fuzhou 350108,China,2.Department of Nephrology of Nanjin Army Fuzhou General Hospital,Fuzhou 350025,China) |
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| Abstract: | AIM:To observe the clinical effects of Huangkui Capsule(Abelmoschus manihot(Linn)Medic.)on the treatment of IgA nephropathy of damp-heat syndrome.METHODS:Sixty-four patients were assigned randomly into two groups:treatment group in which 32 cases were treated with Huangkui Capsule,and control group,in which 32 cases were treated with fosinopril.The therapeutic course for both groups was 12 weeks.The indexes of efficacy,including damp-heat syndrome scores,24 h urinary protein,serum creatinine,urea nitrogen a... |
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| Keywords: | IgA nephropathy damp-heat syndrome Huangkui Capsule fosinopril |
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