Analysis of the actions of cimetidine and metiamide on gastric acid secretion in the isolated guinea pig gastric mucosa |
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| Authors: | Sven Erik Sjöstrand Birgitta Ryberg Lars Olbe |
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| Affiliation: | (1) Department of Pharmacology, AB Hässle, Fack, S-43120 Mölndal, Sweden;(2) Department of Surgery II, Sahlgren's Hospital, S-40033 Göteborg, Sweden |
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| Abstract: | Summary Cumulative dose-response curves for histamine were determined on acid secretion from the isolated guinea pig gastric mucosa. Two H2-receptor antagonists—metiamide and cimetidine—behaved like competitive antagonists to histamine on gastric acid secretion in vitro. The isolated guinea pig gastric mucosa seems to be a suitable in vitro model for analysing the action of compounds on receptors involved in acid secretion. |
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| Keywords: | Guinea pig Isolated stomach Gastric acid secretion Histamine Histamine H2-receptor-antagonists |
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