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异基因造血干细胞移植治疗骨髓增生异常综合征新进展(附视频)
引用本文:王健民.异基因造血干细胞移植治疗骨髓增生异常综合征新进展(附视频)[J].中华移植杂志(电子版),2011,5(4):41-44.
作者姓名:王健民
作者单位:第二军医大学附属长海医院血液科,解放军血液病研究所,上海,200433
摘    要:骨髓增生异常综合征(MDS)是一组异质性很强的疾病,临床上需针对不同类型MDS采取分层治疗,针对不同目的选择个体化治疗方案。近年研究表明,异基因造血干细胞移植(Allo-HSCT)治疗MDS的疗效确切,预后评分系统对MDS移植后的疗效有重要预测作用,年龄对50岁以上各年龄段的MDS患者移植后总体生存的影响不大,非清髓或减低剂量预处理的Allo-HSCT使更多年老体弱患者耐受移植治疗,移植时机是影响Allo-HSCT疗效和预后的重要因素。

关 键 词:骨髓增生异常综合征  异基因造血干细胞移植  预后评分系统  预后  减低剂量预处理  移植时机  视频

Advances of allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes(video)
WANG Jian-min.Advances of allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes(video)[J].Chinese Journal of Transplanation(Electronic Version),2011,5(4):41-44.
Authors:WANG Jian-min
Institution:WANG Jian-min. (Department of Hematology, Changhai Hospital of the Second Military Medical University, Shanghai 200433, China)
Abstract:Myelodysplastic syndromes (MDS) are a group of diseases that involve ineffective production of the myeloid class of blood ceils. The treatment of MDS varies based on different types of MDS. The recent evidence shows that allogeneic hematopoietic stem cell transplantation (Allo HSCT) to treat MDS is with promising outcomes and that prognostic scoring systems are valuable for prognosis of MDS patients after Allo HSCT. Furthermore, the age is not a risk factor for the overall survival of MDS patients after transplantation and the Allo HSCT with nonmyeloablative pretreatment or reduced intensity conditioning makes more elderly patients tolerant to Allo HSCT. However, transplant timing is still an important factor for the Allo HSCT outcomes.
Keywords:Myelodysplastic syndromes  A11ogeneic hematopoietic stem cell transplantation  Prognostic scoring system  Prognosis  Reduced intensity conditioning  Transplant timing  Video
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