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Clinical importance of precursor lesions in the pancreas
Authors:Ralph H Hruban  Kyoichi Takaori  Marcia Canto  Elliot K Fishman  Kurtis Campbell  Kieran Brune  Scott E Kern  Michael Goggins
Institution:1.Department of Pathology,The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions,Baltimore,USA;2.Department of Oncology,The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions,Baltimore,USA;3.Department of General and Gastroenterological Surgery,Osaka Medical College,Osaka,Japan;4.Department of Medicine,The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions,Baltimore,USA;5.Department of Radiology,The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions,Baltimore,USA;6.Department of Surgery,The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions,Baltimore,USA
Abstract:Three distinct noninvasive precursor lesions to invasive ductal adenocarcinoma of the pancreas have been described. These include the mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. The early detection and treatment of these lesions can interrupt the progression of a curable noninvasive precursor to an almost uniformly deadly invasive cancer.
Keywords:pancreas  cancer  precursor  intraductal papillary mucinous neoplasm  pancreatic intraepithelial neoplasia  mucinous cystic neoplasm
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