| 六神巴布剂抗炎药效动力学的研究 |
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| 引用本文： | 余斌,吴正红,李燕,王颖玉,高薇,刘永. 六神巴布剂抗炎药效动力学的研究[J]. 中药新药与临床药理, 2010, 21(1) |
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| 作者姓名： | 余斌 吴正红 李燕 王颖玉 高薇 刘永 |
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| 作者单位： | 1. 中国药科大学药剂教研室,南京,210009
2. 苏州雷允上药业股份有限公司,苏州,215011 |
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| 摘 要： | 目的研究六神巴布剂的抗炎作用及其药效动力学过程,为合理用药提供参考。方法分别用二甲苯致小鼠耳肿模型和角叉菜胶性足肿模型观察六神巴布剂的抗炎作用;并以抗炎效应(肿胀度减少值)为药效指标,进行六神巴布剂的药效动力学研究,通过计算机程序求得相关药动学参数。结果六神巴布剂具有显著的抗炎作用,其药效动力学模型符合一室开放模型。t1/2(Ka)、t1/2(Ke)、AUC分别为2.11727h、3.13464h和3.33131mg·kg·h-1。结论六神巴布剂具有显著的抗炎作用,且药效强度较高,作用时间长,其药效动力学模型为一室开放模型。
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| 关 键 词： | 六神巴布剂 抗炎 药效动力学 |
Anti-inflammatory Action and Pharmacodynamics of Liushen Cataplasm |
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| YU Bin,WU Zhenghong,LI Yan,WANG Yingyu,GAO Wei,LIU Yong. Anti-inflammatory Action and Pharmacodynamics of Liushen Cataplasm[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2010, 21(1) |
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| Authors: | YU Bin WU Zhenghong LI Yan WANG Yingyu GAO Wei LIU Yong |
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| Affiliation: | YU Bin1,WU Zhenghong1,LI Yan1,WANG Yingyu1,GAO Wei1,LIU Yong2(1.Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China,2.Lei Yunshang pharmaceuticals Limited Company,Suzhou 215011,China) |
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| Abstract: | Objective To sutdy the anti-inflammatory action and pharmacodynamics of Liushen Cataplasm (LC). Methods The anti-inflammatory action of LC was observed on mice models of xylene-induced ear swelling and on the rat models of carrageenan-induced pedal swelling. With the decrease of pedal swelling as the parameter,the pharmacodynamics of LC was studied. The apparent parameters of pharmacodynamics were estimated based on the time-effect curve. Results LC showed a potent anti-inflammatory effect. The effect-time ... |
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| Keywords: | Liushen Cataplasm Anti-inflammation Pharmacodynamics |
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