| 内皮素-1反义脱氧寡核苷酸对糖尿病肾病大鼠肾组织形态学的影响 |
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| 引用本文： | 余建强,李玉香,王洁,张焱,王淑静,袁文俊.内皮素-1反义脱氧寡核苷酸对糖尿病肾病大鼠肾组织形态学的影响[J].第四军医大学学报,2009(20):2090-2092. |
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| 作者姓名： | 余建强 李玉香 王洁 张焱 王淑静 袁文俊 |
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| 作者单位： | 宁夏医科大学基础医学院药理学系;宁夏医科大学护理学院基础护理学系;宁夏医科大学科技中心;宁夏医科大学基础医学院生理学系;第二军医大学生理学教研室; |
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| 基金项目： | 宁夏高等学校科学技术研究项目(宁教高[2007]292号-103,宁教高[2007]292-87); 宁夏卫生厅重点科研计划项目(W2008087); 宁夏医科大学科学技术研究项目(XM200832) |
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| 摘 要： | 目的：研究内皮素-1反义脱氧寡核苷酸（ET-1AS—ODN）对链脲佐菌素（streptozotocin，STZ）诱导的糖尿病大鼠肾组织形态学的保护作用及其机制．方法：一次性腹腔注射STZ（60mg／kg），建立大鼠糖尿病模型，观察ET-1AS-ODN预防性给药对大鼠肾组织形态结构的保护作用．结果：ET-1AS—ODN可明显减轻糖尿病大鼠肾肥大指数，改善肾组织形态学损伤．结论：内皮素-1反义寡核苷酸可减轻STZ诱导的糖尿病肾病大鼠的肾损伤，对肾组织具有保护作用．其机制与减少内源性内皮素的产生有关．
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| 关 键 词： | 内皮素-1反义寡核苷酸 糖尿病肾病 形态学 内皮素 |
Protective effects of endothelin-1 mRNA antisense oligodeoxynucleotide on the kidney ultrustructure of streptozotocin-induced diabetic nephropathy rats |
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| YU Jian-Qiang,LI Yu-Xiang,WANG Jie,ZHANG Yan,WANG Shu-Jing,YUAN Wen-Jun.Protective effects of endothelin-1 mRNA antisense oligodeoxynucleotide on the kidney ultrustructure of streptozotocin-induced diabetic nephropathy rats[J].Journal of the Fourth Military Medical University,2009(20):2090-2092. |
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| Authors: | YU Jian-Qiang LI Yu-Xiang WANG Jie ZHANG Yan WANG Shu-Jing YUAN Wen-Jun |
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| Institution: | YU Jian-Qiang1,LI Yu-Xiang2,WANG Jie3,ZHANG Yan3,WANG Shu-Jing3,YUAN Wen-Jun4,51Department of Pharmacology,Basic Medicine and Research College,2Nursing School,3Science and Technology,4Department of Physiology,Ningxia Medical University,Yinchuan 750004,China,5Department of Physiology,Second Military Medical University,Shanghai 200003 |
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| Abstract: | AIM:To investigate the protective effects of endothelin-1 mRNA antisense oligodeoxynucleotide(ET-1 AS-ODN)on the renal morphology of diabetic nephropathy(DN)and discuss the pathogenesis and mechanism of DN in a diabetic rat model.METHODS:Diabetic rats were induced by intraperitoneal administration of streptozotocin(STZ)at 60 mg/kg.ET-1 AS-ODN was administrated intravenously to the treatment groups and its protective effects on renal morphology were observed.RESULTS:Compared with the DM group,the kidney inde... |
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| Keywords: | endothelin-1 mRNA antisense oligodeoxynucleotide diabetic nephropathy morphology endothelin |
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