| 乙酰丹参素单硝酸异山梨醇酯的合成及对心肌缺血／再灌注大鼠心脏的保护作用 |
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| 引用本文： | 向卓,景临林,刘文冲,王平安,高峰,孙晓莉. 乙酰丹参素单硝酸异山梨醇酯的合成及对心肌缺血／再灌注大鼠心脏的保护作用[J]. 医学争鸣, 2009, 0(14): 1257-1261 |
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| 作者姓名： | 向卓 景临林 刘文冲 王平安 高峰 孙晓莉 |
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| 作者单位： | 第四军医大学药学系化学教研室;第四军医大学基础部生理学教研室; |
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| 基金项目： | “重大新药创制”科技重大专项(2009ZX09103) |
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| 摘 要： | 目的：考察乙酰丹参素单硝酸异山梨醇酯（AcDI-302）对心肌缺血／再灌注（MIfR）大鼠的心肌保护作用，并与单硝酸异山梨醇酯（ISMN）进行比较。方法：常规制备大鼠MI/R（30min／3h）模型。随机分为假手术组，MI／R组，（MI／R＋ISMN）组，（MI／R＋AcDI-302）组。观察各组大鼠缺血30min再灌注3h心功能恢复情况和3h末血清中肌酸激酶（CK）、乳酸脱氢酶（LDH）活性和丙二醛（MDA）的水平及NO的含量。结果：MI／R＋AcDI-302组大鼠较ISMN组心肌梗死范围明显减小，血清中CK，LDH活性和MDA浓度也显著降低，左室收缩压（LVSP）、左室等容收缩／舒张期压力上升或下降最大速率（±dp／dtmax）显著提高。结论：AcDI-302对心肌缺血再灌注损伤大鼠的心肌有保护作用，作用强于ISMN。
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| 关 键 词： | 乙酰丹参素单硝酸异山梨醇酯 丹参素 单硝酸异山梨酯 一氧化氮供体 心肌缺血 再灌注损伤 |
Protective effect of Acetyl Danshen Acid Isosorbide Mononitrate on myocardial ischemia/reperfusion injury in rats |
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| XIANG Zhuo,JING Lin-Lin,LIU Wen-Chong,WANG Ping-An,GAO Feng,SUN Xiao-Li. Protective effect of Acetyl Danshen Acid Isosorbide Mononitrate on myocardial ischemia/reperfusion injury in rats[J]. Negative, 2009, 0(14): 1257-1261 |
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| Authors: | XIANG Zhuo JING Lin-Lin LIU Wen-Chong WANG Ping-An GAO Feng SUN Xiao-Li |
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| Affiliation: | XIANG Zhuo1,JING Lin-Lin1,LIU Wen-Chong2,WANG Ping-An1,GAO Feng2,SUN Xiao-Li1 1Department of Chemistry,2Department of Physiology,Fourth Military Medical University,Xi'an 710032,China |
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| Abstract: | AIM:To study the protective effect of a new compound,Acetyl Danshen Acid Isosorbide Mononitrate(AcDI-302),on myocardial ischemia/reperfusion(MI/R) injury and to compare its effect with that of Isosorbide Mononitrate(ISMN).METHODS: Male Sprague-Dawley rats were subjected to 30 min of myocardial ischemia and 3 h of reperfusion.The rats were randomly assigned to SHAM group,treatment group of MI/R+solvent and MI/R+ISMN and treatment group of MI/R+AcDI-302.MI/R models were prepared by temporary occlusion of the ... |
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| Keywords: | acetyl danshen acid isosorbide mononitrate danshensu isosorbide mononitrate nitric oxide donors myocardial ischemia reperfusion injury |
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