甲状腺内胎儿微嵌合体在产后Graves病发病的影响

目的：探讨甲状腺内胎儿微嵌合体对女性产后Graves病发病的影响.方法：选用Y染色体α卫星区特异性DNA探针,利用荧光原位杂交技术,检测24例GD和10例甲状腺腺瘤患者甲状腺石蜡标本中的胎儿嵌合体的存在.结果：24例产后GD患者甲状腺标本中13例发现存在着Y染色体,10例甲状腺腺瘤对照组中仅2例存在有Y染色体.两组间胎儿微嵌合体的出现率存在显著性差异（54.2%vs20%,P〈0.05）.比较GD患者中胎儿嵌合体阳性和阴性病例的的临床资料,显示胎儿嵌合体阳性组患者的妊娠次数（平均2.77±0.38次）显著多于胎儿微嵌合体阴性组（平均1.36±0.27次）（P〈0.05）.结论：胎儿微嵌合体在GD患者甲状腺内出现的机率的确较非AITD的患者更高,提示胎儿微嵌合体可能参与产后GD的发生.

Influence of the microchemirism in the thyroid glangs to post-partum Graves' disease

AIM：To explain the influence of the fetal microchemirism in the thyroid tissue to post-partum Graves＇ disease（GD）.METHODS：Twenty-four GD thyroid tissue samples and 10 adenoma thyroid tissue samples were collected from the first hospital of Xi＇an Jiaotong University.Using the Y chromosome special α-satellite-region probes,the Y chromosome in the female patients＇ thyroid tissue was test by fluorescence insitu hybridization（FISH）.RESULTS：The difference in the appearance ratio of male cells between Graves＇ disease and adenoma was statistically significant（54.2% vs 20%,P〈0.05）.Compared the clinical history of the patients,we found the pregnancy times of male-cells-positive GD patients was more than that of male-cells-negative GD patients（2.77±0.38 vs 1.36±0.27,P〈0.05）.CONCLUSION：Intrathyroidal fetal microchimerism are probably involved in the pathogenesis of post-partum GD.And the pregnancy times was the major role that influent the present of the fetal microchimerism.