| 福建地区汉族人乙型肝炎肝硬化与人类白细胞抗原Ⅰ类基因的相关性 |
| |
| 引用本文： | 李东良,郑建勇,彭经宙,赵书民,杨才生,林小钦,程变巧.福建地区汉族人乙型肝炎肝硬化与人类白细胞抗原Ⅰ类基因的相关性[J].第四军医大学学报,2009(18):1703-1706. |
| |
| 作者姓名： | 李东良 郑建勇 彭经宙 赵书民 杨才生 林小钦 程变巧 |
| |
| 作者单位： | 南京军区福州总医院肝胆内科;第四军医大学西京消化病医院;第二军医大学长征医院感染科; |
| |
| 基金项目： | 福建省自然科学基金(2006J0120) |
| |
| 摘 要： | 目的：研究人白细胞抗原（HLA）-A基因多态性与福建地区汉族人乙型肝炎肝硬化的遗传易感性关系．方法：以93例福建地区汉族人群乙型肝炎肝硬化患者（病例组）为研究对象，以同一地区84例健康人为对照人群（对照组），采用DNA测序分型技术（SBT）对HLA—A等位基因精确分型，计算各组等位基因频率．对对照人群等位基因分布进行Hardy—Weinberg遗传平衡检验，应用遗传统计方法进行关联分析，确定与乙型肝炎肝硬化相关的易感基因及基因型．结果：HLA—A等位基因差异显著性检验：病例组A＊24（20．33％vs9．52％，x^2=7．938，P=0．005），A＊2402（19．23％vs8．33％，x^2=7．212，P=0．009）和A＊01（5．49％vs1．19％，x^2=4．878，P=0．027），A＊0101（4．95％vs0．60％，x^2=5．955，P=0．015）等位基因频率明显高于对照组．病例组A＊33（3．85％vs9．52％，x^2=4．587，P=0．032），A＊3303（4．40％vs9．52％，x^2=4．440，P=0．032）基因频率也低于对照组．等位基因多因素分析：HLA—A＊24主型（OR=2．397，95％CI：1．206～4．766，P=0．0126）和A＊2402亚型（OR=2．685，95％CI：1．306～5．521，P：0．0072）在病例组与对照组之间分布差异具有显著性．基因型多因素分析：A2402（OR=3．254，95％CI：1．320～8．021，x^2=6．5703，P=0．0104）和A0201（OR=2．411，95％CI：1．147～5．068，x^2=5．399，P=0．0203）在病例组与对照组之间的差异也具有显著性．基因型剂量一效应关系分析：乙型肝炎肝硬化与H1A—A2402基因型剂量线性相关（OR=2．020，95％CI：1．095—3．728，x^2=5．0624，P=0．0244）．结论：HLA-A＊2402等位基因及其基因型与乙型肝炎肝硬化存在阳性关联，可能是慢性乙型肝炎病毒感染肝硬化形成的易感基因．
|
| 关 键 词： | 乙型肝炎 肝硬化 人类白细胞抗原 基因频率 基因分型 |
HLA-A gene polymorphism in Fujian Han population with HBV-induced liver cirrhosis |
| |
| LI Dong-Liang,ZHENG Jian-Yong,PENG Jing-Zhou,ZHAO Shu-Min,YANG Cai-Sheng,LIN Xiao-Qing,CHENG Bian-QiaoDepartemnt of Hepatobiliary Medicine,Fuzhou General Hospital,Nanjing Military Area Comm,Fuzhou ,China,Hospital of Digestive Diseases,Fourth Military Medical University,Xi'an.HLA-A gene polymorphism in Fujian Han population with HBV-induced liver cirrhosis[J].Journal of the Fourth Military Medical University,2009(18):1703-1706. |
| |
| Authors: | LI Dong-Liang ZHENG Jian-Yong PENG Jing-Zhou ZHAO Shu-Min YANG Cai-Sheng LIN Xiao-Qing CHENG Bian-QiaoDepartemnt of Hepatobiliary Medicine Fuzhou General Hospital Nanjing Military Area Comm Fuzhou China Hospital of Digestive Diseases Fourth Military Medical University Xi'an |
| |
| Institution: | LI Dong-Liang1,ZHENG Jian-Yong2,PENG Jing-Zhou1,ZHAO Shu-Min3,YANG Cai-Sheng1,LIN Xiao-Qing1,CHENG Bian-Qiao11Departemnt of Hepatobiliary Medicine,Fuzhou General Hospital,Nanjing Military Area Command,Fuzhou 350025,China,2Hospital of Digestive Diseases,Fourth Military Medical University,Xi'an 710033,3Department of Infectious Diseases,Changzheng Hospital,Second Military Medical University,Shanghai 200003 |
| |
| Abstract: | AIM: To investigate the association between HLA-A gene polymorphism and the genetic susceptibility to HBV-induced liver cirrhosis in Fujian Han population.METHODS: Genotyping of HLA-A gene was performed in 93 patients with HBV-induced cirrhosis and 84 healthy individuals by SBT(Sequencing-Based Typing).The distribution of alleles in control group was checked by Hardy-Weinberg genetic equilibrium and the association between the disease and the frequencies of alleles was analyzed by genetic statistical method... |
| |
| Keywords: | hepatitis B liver cirrhosis HLA gene frequency genotyping |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
