| 白藜芦醇对大鼠脊髓损伤的保护作用 |
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| 引用本文： | 刘长江,孙朝阳. 白藜芦醇对大鼠脊髓损伤的保护作用[J]. 医学争鸣, 2009, 30(13): 1199-1201 |
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| 作者姓名： | 刘长江 孙朝阳 |
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| 作者单位： | 西安交通大学体育部;西安交通大学生物医学信息工程教育部重点实验室;西安交通大学医院内科,陕西,西安,710049 |
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| 摘 要： | 目的：建立Allens脊髓模型,探讨白藜芦醇（Res）对大鼠脊髓损伤（SCI）的保护效果.方法：将24只SD大鼠随机分为假手术组（A组）,脊髓打击损伤组（B组）,Res组（C组）,每组8只.A,B组根据自制改良的Allens装置制备脊髓急性打击损伤动物模型.脊髓打击损伤后即刻腹腔注射Res100mg/kg,观察并检测3组大鼠SCI后24,48,72h3个不同时间点后肢运动功能评分变化及脊髓组织病理学、超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量改变.结果：术后A组大鼠功能完全恢复.B组和C组大鼠后肢运动功能24,48,72h3个时间点均有所改善.但24h时差异明显（P〈0.05）;48,72h时差异更为显著（P〈0.01）.A组神经组织结构完好,神经元轮廓清楚,核仁清晰可见,胞质均匀深染.脊髓打击损伤后72hB组神经组织多灶性出血并出现广泛的神经元坏死,尼氏体溶解消失,核固缩变小.C组神经组织结构损伤轻微,细胞轻度肿胀,胞质均匀.术后A组脊髓组织SOD活性升高,而MDA含量则处于较低水平.B组SOD活性明显降低,MDA含量明显升高,与A组相比较差异显著（P〈0.01）.C组与B组相比较,SOD活性明显升高,MDA含量明显降低,差异具有统计学意义（P〈0.01）.结论：Res能明显促使SCI后的功能恢复,对SCI具有一定的保护作用.
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| 关 键 词： | 白藜芦醇 脊髓损伤 保护作用 大鼠 |
Protective effect of Resveratrol on spinal cord injury in rats |
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| LIU Chang-Jiang,SUN Chao-Yang. Protective effect of Resveratrol on spinal cord injury in rats[J]. Negative, 2009, 30(13): 1199-1201 |
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| Authors: | LIU Chang-Jiang SUN Chao-Yang |
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| Affiliation: | LIU Chang-Jiang1,2,SUN Chao-Yang31Department of Physical Education,2MOE Key Laboratory of Biomedical Information Engineering,3Department of Internal Medicine,Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710049,China |
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| Abstract: | AIM:To study the protective effects of Resveratrol (Res) on spinal cord injury in rats. METHODS: Twenty-four SD rats were randomly divided into 3 groups: Sham-operation group(group A), spinal cord injury group(group B) and Res group(group C). Animal models of acute spinal cord were induced with Allen's method. In RES group, Res of 100 mg/kg was injected through abdomen immediately after modeling. The locomotor function of the hind limbs and the histopathological as well as superoxide dismutase(SOD) and malo... |
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| Keywords: | resveratrol spinal cord injury protective effects rats |
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