| 局部制动对大鼠胰岛素敏感性影响的研究 |
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| 引用本文： | 王玉,伍兵. 局部制动对大鼠胰岛素敏感性影响的研究[J]. 医学争鸣, 2009, 0(19) |
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| 作者姓名： | 王玉 伍兵 |
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| 作者单位： | 成都体育学院运动医学系;四川大学华西医院放射科; |
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| 基金项目： | 四川省科技厅应用基础项目(07JY029-117); 国家体育总局运动医学重点实验室专项基金 |
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| 摘 要： | 目的:了解肢体制动对大鼠胰岛素敏感性的影响.方法:将SD大鼠随机分为对照组、制动组,每组20只.制动组大鼠右后肢石膏固定,对照组不做特殊处理.3wk后将两组大鼠行高胰岛素—正常葡萄糖钳夹技术,术后分离大鼠右比目鱼肌测量质量、肌细胞直径及肌纤维截面积.结果:制动组稳态葡萄糖输入速率[(35±5)mg(/kg·h)vs(13±4)mg/(kg.h)]、右侧比目鱼肌湿质量[(169.2±4.1)gvs(67.1±6.3)g]、肌细胞直径[(49.8±2.7)μmvs(20.6±3.2)μm]、肌纤维截面积[(998±21)μm2vs(579±14)μm2]均明显低于对照组.结论:局部制动可导致大鼠骨骼肌萎缩,并使机体对胰岛素的敏感性降低.
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| 关 键 词： | 胰岛素敏感性 高胰岛素-正糖钳夹 制动 骨骼肌萎缩 |
Effect of limb immobilization on insulin sensitivity in rats |
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| WANG Yu,WU Bing. Effect of limb immobilization on insulin sensitivity in rats[J]. Negative, 2009, 0(19) |
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| Authors: | WANG Yu WU Bing |
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| Affiliation: | WANG Yu1,WU Bing21Department of Sport Medicine,Chengdu Sport University,Chengdu 610041,China,2Department of Radiology,West China Hospital,Sichuan University |
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| Abstract: | AIM:To observe the effects of limb immobilization on the insulin sensitivity.METHODS:Sprague-Dawley rats were randomly assigned to 2 groups:control(CON)and three-week immobilization(IB).The right legs of the rats in IB group were immobile for three weeks.After the 3 weeks,hyperinsulinem ic-euglycemic clamp was used to evaluate the insulin sensitivity and soleus muscles were dissected and weighted.The diameter and cross section area of muscle cell were measured.RESULTS:In IB group,the wet weights of the sole... |
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| Keywords: | insulin sensitivite hyperinsulinem ic-euglycem ic clamp Immobilization soleus atrophy |
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