| 人参总皂苷合黄连小檗碱对慢性心衰大鼠心肌肌球蛋白重链的影响 |
| |
| 引用本文： | 李永民,陈晓春,罗飞,李刚. 人参总皂苷合黄连小檗碱对慢性心衰大鼠心肌肌球蛋白重链的影响[J]. 医学争鸣, 2009, 30(14): 1281-1284 |
| |
| 作者姓名： | 李永民 陈晓春 罗飞 李刚 |
| |
| 作者单位： | 河北北方学院中医系中药教研室,河北,张家口,075000;河北北方学院第一附属医院神经内科,河北,张家口,075000 |
| |
| 基金项目： | 河北省科技支撑计划(08276101D-65) |
| |
| 摘 要： | 目的:探讨人参总皂苷(GS)合黄连小檗碱(Ber)对慢性心衰大鼠心肌肌球蛋白重链(α-MHC,β-MHC)表达的影响.方法:连续12 d皮下注射较大量异丙肾上腺素(ISO)建立慢性心衰大鼠模型,ISO总量80 mg/kg,随机分为模型组、GS+Ber组、卡托普利组、参麦注射液组,另设对照组.GS+Ber组各以20 mg/(kg.d)灌胃,卡托普利组以45 mg/(kg.d)灌胃,参麦注射液组以5 mL/(kg.d)腹腔注射,模型组和对照组以蒸馏水灌胃.4 wk后检测各组血流动力学指标、心脏质量指数,实时荧光定量PCR检测α-MHC,β-MHC mRNA表达.结果:对照组与各组相比,左室内压峰值(LVSP)、左室等容收缩期压力上升最大速率(+dp/dtmax)、左室舒张期压力下降最大速率(-dp/dtmax)以及α-MHC mRNA表达明显下降,左室舒张末压(LVEDP)、心脏质量指数以及β-MHC mRNA表达显著升高(均P<0.01);GS+Ber组、卡托普利组与模型组相比,LVSP,±dp/dtmax,α-MHC mRNA表达明显升高,LVEDP、心脏质量指数以及β-MHC mRNA表达显著降低(P<0....
|
| 关 键 词： | 人参皂甙类 黄连小檗碱 心力衰竭 充血性 血液动力学现象 心肌肌球蛋白重链 |
Effects of total ginsenoside combined with berberine on cardiac myosin heavy chain in experimental rats with chronic congestive heart failure |
| |
| LI Yong-Min,CHEN Xiao-Chun,LUO Fei,LI Gang Section of Chinese Medicine , Recipe. Effects of total ginsenoside combined with berberine on cardiac myosin heavy chain in experimental rats with chronic congestive heart failure[J]. Negative, 2009, 30(14): 1281-1284 |
| |
| Authors: | LI Yong-Min CHEN Xiao-Chun LUO Fei LI Gang Section of Chinese Medicine Recipe |
| |
| Affiliation: | LI Yong-Min1,CHEN Xiao-Chun2,LUO Fei1,LI Gang1 1Section of Chinese Medicine and Recipe,Department of Traditional Chinese Medicine,2Department of Neurology,First Affiliated Hospital,Hebei North University,Zhangjiakou 075029,China |
| |
| Abstract: | AIM: To study the effects of total ginsenoside(GS)combined with berberine(Ber)on the expression of cardiac myosin heavy chain in cardiac cells of chronic congestive heart failure rats.METHODS: Animal models of heart failure were induced by subcutaneous injection of a large dose of ISO(80 mg/kg) for 12 d and were randomly divided into model group,GS+Ber group,captopril group and shenmai injection group.Some other rats served as control group.GS+Ber group were treated with total ginsenoside and berberine(each... |
| |
| Keywords: | ginsenosides berberine heart failure congestive hemodynamic phenomena cardiac myosin heavy chain |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
