银杏叶提取物对体外循环细胞因子的干预作用

目的：探讨体外循环脑损伤的发生机制及银杏叶提取物的干预作用．方法：选择44例心脏病需体外循环手术的风湿性心脏瓣膜病患者，随机分为观察组和对照组，每组22例．观察组在体外循环予充液中加入银杏叶提取物2mg／kg体质量，对照组应用常规予充液．分别在术前、主动脉阻断后1h，术后6，12，24和48h抽取静脉血标本，检测血清IL-1β，IL-18和S100蛋白水平．结果：对照组自CPB结束即刻开始，血清IL-1β显著升高，观察组血清IL-1β自主动脉阻断1h开始升高，持续至术后48h，自主动脉阻断1h开始，对照组显著低于观察组．对照组自术后6h开始，血清IL-18持续升高至术后48h，观察组血清IL-18主动脉阻断1h开始，血清IL-18持续升高至术后48h，主动脉阻断1h，对照组血清IL-18低于观察组，但术后6，12，24，48h显著高于观察组．对照组S100蛋白自CPB结束开始升高，持续至实验结束，自主动脉阻断1h开始至术后48h血清S100蛋白水平对照组均显著高于观察组．结论：体外循环心脏直视手术细胞因子IL-18参与脑组织损伤过程，GBE可调节细胞因子，使血清S100蛋白显著降低．

Effects of GBE on the cytokines during open heart surgery with cardiopulmonary bypass

AIM: To explore the effect of GBE on cerebral injury caused by cardiac operation with CPB.METHODS: Forty four patients with rheumatic heart diseases undergoing cardiac valvular replacement with CPB were selected.The patients were divided into 2 groups randomly: study group and control group,22 in each group.In study group,GBE(2 mg/kg wt) was added into the CPB prime solution,whereas in control group,normal solution was adopted.Blood samples were collected at preoperation,1 h after aortic cross-clamp,6 h,12 ...