| 银杏叶提取物对体外循环细胞因子的干预作用 |
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| 引用本文： | 付庆林,张新中,韩培立,张小路,Robert J Cusimano.银杏叶提取物对体外循环细胞因子的干预作用[J].第四军医大学学报,2009(18):1721-1724. |
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| 作者姓名： | 付庆林 张新中 韩培立 张小路 Robert J Cusimano |
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| 作者单位： | 新乡医学院第一附属医院博士后工作站;加拿大多伦多; |
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| 基金项目： | 博士后基金资助项目(57068) |
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| 摘 要： | 目的：探讨体外循环脑损伤的发生机制及银杏叶提取物的干预作用．方法：选择44例心脏病需体外循环手术的风湿性心脏瓣膜病患者，随机分为观察组和对照组，每组22例．观察组在体外循环予充液中加入银杏叶提取物2mg／kg体质量，对照组应用常规予充液．分别在术前、主动脉阻断后1h，术后6，12，24和48h抽取静脉血标本，检测血清IL-1β，IL-18和S100蛋白水平．结果：对照组自CPB结束即刻开始，血清IL-1β显著升高，观察组血清IL-1β自主动脉阻断1h开始升高，持续至术后48h，自主动脉阻断1h开始，对照组显著低于观察组．对照组自术后6h开始，血清IL-18持续升高至术后48h，观察组血清IL-18主动脉阻断1h开始，血清IL-18持续升高至术后48h，主动脉阻断1h，对照组血清IL-18低于观察组，但术后6，12，24，48h显著高于观察组．对照组S100蛋白自CPB结束开始升高，持续至实验结束，自主动脉阻断1h开始至术后48h血清S100蛋白水平对照组均显著高于观察组．结论：体外循环心脏直视手术细胞因子IL-18参与脑组织损伤过程，GBE可调节细胞因子，使血清S100蛋白显著降低．
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| 关 键 词： | 体外循环 细胞因子 银杏叶提取物 |
Effects of GBE on the cytokines during open heart surgery with cardiopulmonary bypass |
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| FU Qing-Lin,ZHANG Xin-Zhong,HAN Pei-Li,ZHANG Xiao-Lu,Robert J CusimanoPostdoctoral Station,First Affiliated Hospital,Xinxiang Medical University,Xinxiang ,China,Pater Munk Cardiac Center,Toronto General Hospital,Toronto MG C,Canada.Effects of GBE on the cytokines during open heart surgery with cardiopulmonary bypass[J].Journal of the Fourth Military Medical University,2009(18):1721-1724. |
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| Authors: | FU Qing-Lin ZHANG Xin-Zhong HAN Pei-Li ZHANG Xiao-Lu Robert J CusimanoPostdoctoral Station First Affiliated Hospital Xinxiang Medical University Xinxiang China Pater Munk Cardiac Center Toronto General Hospital Toronto MG C Canada |
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| Institution: | FU Qing-Lin1,ZHANG Xin-Zhong1,HAN Pei-Li1,ZHANG Xiao-Lu1,Robert J Cusimano21Postdoctoral Station,First Affiliated Hospital,Xinxiang Medical University,Xinxiang 453100,China,2Pater Munk Cardiac Center,Toronto General Hospital,Toronto M5G 2C4,Canada |
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| Abstract: | AIM: To explore the effect of GBE on cerebral injury caused by cardiac operation with CPB.METHODS: Forty four patients with rheumatic heart diseases undergoing cardiac valvular replacement with CPB were selected.The patients were divided into 2 groups randomly: study group and control group,22 in each group.In study group,GBE(2 mg/kg wt) was added into the CPB prime solution,whereas in control group,normal solution was adopted.Blood samples were collected at preoperation,1 h after aortic cross-clamp,6 h,12 ... |
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| Keywords: | cardiopulmonary bypass cytokine GBE |
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