| 金匮肾气丸对大鼠肾阳虚症的干预研究 |
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| 引用本文： | 刘贺亮,陈长生,王文勇,张金山,袁建林,秦军,杨波.金匮肾气丸对大鼠肾阳虚症的干预研究[J].第四军医大学学报,2009(20). |
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| 作者姓名： | 刘贺亮 陈长生 王文勇 张金山 袁建林 秦军 杨波 |
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| 作者单位： | 第四军医大学西京医院泌尿外科;第四军医大学卫生统计学教研室;第四军医大学病理学与病理生理学教研室;第四军医大学人体解剖学与组织胚胎学教研室; |
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| 基金项目： | 国家自然科学基金(30772683); 陕西省科技计划攻关项目(2008K04-02); 陕西省自然科学基金(SJ08-ZT10) |
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| 摘 要： | 目的:探讨金匮肾气丸对生精功能障碍大鼠的影响及作用机理.方法:成年雄性SD大鼠100只随机分成5组:空白对照组(正常组)、高剂量组、中剂量组、低剂量组、模型组,除正常组外,其他组大鼠用氢化可的松注射液制造肾阳虚模型.在造模的同时分别对高、中、低剂量组用金匮肾气丸混悬液灌胃,连续用药30d.测血清睾酮含量,取附睾液镜下观察精子密度和活动百分率,光镜观察睾丸的显微结构.结果:金匮肾气丸可使生精功能障碍大鼠上述指标得到一定程度的改善,并趋近于空白对照组水平.结论:金匮肾气丸对大鼠肾阳虚模型有一定的治疗作用.
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| 关 键 词： | 金匮肾气丸 肾阳虚症 生精功能障碍 睾酮 |
Intervention effect of Jinkuishenqiwan on the kidney-yang deficiency in rats |
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| LIU He-Liang,CHEN Chang-Sheng,WANG Wen-Yong,ZHANG Jin-Shan,YUAN Jian-Lin,QIN Jun,YANG Bo.Intervention effect of Jinkuishenqiwan on the kidney-yang deficiency in rats[J].Journal of the Fourth Military Medical University,2009(20). |
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| Authors: | LIU He-Liang CHEN Chang-Sheng WANG Wen-Yong ZHANG Jin-Shan YUAN Jian-Lin QIN Jun YANG Bo |
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| Institution: | LIU He-Liang1,CHEN Chang-Sheng2,WANG Wen-Yong3,ZHANG Jin-Shan4,YUAN Jian-Lin1,QIN Jun1,YANG Bo1 1Department of Urology,Xijing Hospital,2Department of Health Statistics,3Department of Pathology and Pathophysiology,4Department of Human Anatomy and Histology & Embryology,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | AIM:To explore the ability and mechanism of Jinkuishenqiwan to inhibit the spemratgoenic arrest infertile.METHODS:One hundred mature male rats were divided into 5 groups randomly:Blank group,model group,treated group with high dosage Jinkuishenqiwan,with middle dosage Jinkuishenqiwan,with low dosage Jinkuishenqiwan.Except the normal group,the others were made into model of kidney-yang deficiency by injecting hydrocortisone.simultaneityly the treatment of Jinkuishenqiwan also was irrigated into the stomachs ... |
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| Keywords: | Jinkuishenqiwan model of kidney-yang deficiency spermatogenic arrest testosterone |
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