Lateral Cell Membranes and Shunt Resistance in Rabbit Esophageal Epithelium |
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| Authors: | Nelia A Tobey Zorka Djukic Luisa E Brighton Todd M Gambling John L Carson Roy C Orlando |
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| Institution: | (1) The Department of Medicine, University of North Carolina, Chapel Hill, NC 27599-7310, USA;(2) The Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599-7310, USA;(3) The Department of Pediatrics and the Center For Environmental Medicine, Asthma, and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7310, USA;(4) University of North Carolina School of Medicine, 103 Mason Farm Road, MBRB; CB#7032, Chapel Hill, NC 27599-7032, USA |
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| Abstract: | Background and Aims The structures that contribute to shunt resistance (Rs) in esophageal epithelium are incompletely understood, with 35–40%
of Rs known to be calcium-dependent, reflecting the role of e-cadherin. Two calcium-independent candidates for the remaining
~60% of Rs have been identified: the glycoprotein matrix (GPM) within stratum corneum of esophageal epithelium, and the lateral
cell membranes (LCMs) from neighboring cells. |
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