频域光学相干断层成像术检测视网膜神经纤维层容积的研究

目的 采用频域光学相干断层成像术测量正常人视乳头旁视网膜神经纤维层(Retina nerve fiberlayer,RNFL)容积,分析视乳头旁神经纤维层立体结构,为评价视神经、视网膜等疾病的神经纤维层容积改变提供参考数据.方法 368名健康人经视力、眼压、裂隙灯、屈光和眼底等常规眼科检查,排除青光眼、视神经和视网膜等影响RNFL疾患后,行双眼以视乳头为中心的三维光学相干断层扫描.每名受检者随机抽取一眼的测量结果进行统计.结果 正常人视乳头旁RNFL平均容积以下方象限最大(0.558±0.059)mm~3,上象限次之(0.549±0.059)mm~3,鼻侧偏小(0.347 ±0.049)mm~3,颞侧最小(0.321±0.043)mm~3;不同性别、眼别之间各象限RNFL平均容积没有差异;鼻、颞象限的RNFL容积在各年龄组之间没有差异,而上、下象限在各年龄组之间的差异具有统计学意义.结论 频域光学相干断层成像术能够精确地测量RNFL容积,研究初步建立正常人视乳头旁RNFL容积数据库,为今后临床和科研提供参考.

Retinal Nerve Fiber Layer Volume Measured by Frequency-domain Optical Coherence Tomography in Normal Chinese

Objective To measure peripapillary retinal nerve layer (RNFL) volume in normal Chi- nese using frequency-domain optical coherence tomography (FD-OCT).Methods A total of 368 Chinese par-ticipants underwent a general ophthalmic examination,including measurement of the visual acuity,intraocular pressure and diopter,examination by the ophthalmoscope and slitlump.None of participants had glaucoma or disease of the optical nerve and retina.Three-dimensioual scan of the optical nerve disc were performed on each eye of all participants by OCT (3D OCT-1000;Topcon).Data for one randomly selected eye of each subject were used for statistical analysis.Results The peripapillary RNFL volume was biggest in the inferior (0.558±0.059 mm~3) and superior (0.549±0.059 mm~3) quadrants,followed by the nasal (0.347±0.049mm~3) and tem-poml (0.321±0.043mm~3 quadrants,F=2154.145,P<0.01).There were no gender-related differences in peripapillary RNFL volume.There Were age-related differences in the inferior and superior quadrants,but no statistical differences in the nasal and temporal quadrants.Conehsions Peripapillary RNFL volume is determined by FD-OCT for a normal Chinese population.The normative data from this study may offer valuable information to enable reference to ocular diseases,which can involve RNFL,and comparisons between different populations.