| NO在大鼠海马慢性应激损伤中的作用 |
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| 引用本文： | 胡旺平,胡圣望,化长林. NO在大鼠海马慢性应激损伤中的作用[J]. 咸宁医学院学报, 2003, 17(3): 158-160 |
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| 作者姓名： | 胡旺平 胡圣望 化长林 |
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| 作者单位： | 咸宁学院医学院生理学教研室 湖北咸宁437100(胡旺平，胡圣望)，咸宁学院医学院生理学教研室 湖北咸宁437100(化长林) |
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| 基金项目： | 湖北省教育厅重点课题资助项目 (0 2A4 0 0 3) |
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| 摘 要： | 目的 探讨NO在海马慢性应激损伤中的作用。方法 采用微量注射法、Nissl染色法和生化检测观察海马微量注射N—硝基左旋精氨酸(L—NNA)对慢性应激大鼠海马神经元数量、NO和丙二醛(MDA)含量、一氧化氮合酶(NO6)和超氧化物歧化酶(SOD)活性的影响。结果 海马内微量注射L—NNA对慢性应激引起的海马神经元数量减少，NO和MDA含量增多，NOS活性增高及SOD活性下降有明显改善作用。结论 NO参与了慢性应激对海马的损伤，可能与其产生的自由基损害有关。
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| 关 键 词： | NO 大鼠 海马 慢性应激损伤 作用 |
| 文章编号： | 1008-0635(2003)03-0158-03 |
| 修稿时间： | 2003-02-25 |
Role of NO in the Hippocampus Injury by Chronic Stress in Rats |
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| HU Wang-ping,HU Sheng-wang,HUA Chang-lin. Role of NO in the Hippocampus Injury by Chronic Stress in Rats[J]. Journal of Xianning Medical College, 2003, 17(3): 158-160 |
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| Authors: | HU Wang-ping HU Sheng-wang HUA Chang-lin |
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| Abstract: | Objective To explore the role in hippocampus injury by chronic stress.Methods L-NNA was microinjected into the hippocampus of chronic stressed rats,and then Nissl staining and biochemical assay were done to test the number of hippocampal neurons,the content of NO and malondialdehyde(MDA),the activing of nitric oxide synthase(NOS) and superoxide dismutase (SOD).Results Microinjection of L-NNA into the hippocampus markedly alleviated the decrease in hippocampus neuron number,the increase in NO and MDA content,the heightening of NOS activing and the dropping of SOD activing,caused by chronic stress.Conclusion NO is involved in the hippocampus injury caused by chronic stress,and it may be associated with the production of free radicals. |
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| Keywords: | Stress Nitric oxide Injury Hippocampus |
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