Escherichia coli O157:H7 Requires Intimin for Enteropathogenicity in Calves |
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| Authors: | Evelyn A Dean-Nystrom Brad T Bosworth Harley W Moon and Alison D O&#x;Brien |
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| Institution: | Evelyn A. Dean-Nystrom, Brad T. Bosworth, Harley W. Moon, and Alison D. O’Brien |
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| Abstract: | Enterohemorrhagic Escherichia coli (EHEC) strains require intimin to induce attaching and effacing (A/E) lesions in newborn piglets. Infection of newborn calves with intimin-positive or intimin-negative EHEC O157:H7 demonstrated that intimin is needed for colonization, A/E lesions, and disease in cattle. These results suggest that experiments to determine if intimin-based vaccines reduce O157:H7 levels in cattle are warranted. |
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