| 口腔鳞癌COX-2表达和肿瘤血管生成的研究 |
| |
| 引用本文： | 李晓光,高德安,张丽,王延秀,杨宪勇,王青.口腔鳞癌COX-2表达和肿瘤血管生成的研究[J].北京口腔医学,2006,14(3):164-166. |
| |
| 作者姓名： | 李晓光 高德安 张丽 王延秀 杨宪勇 王青 |
| |
| 作者单位： | 271000,山东省泰安市中心医院口腔科;271000,山东省泰安市中心医院麻醉科;271000,山东省泰安市中心医院中心实验室;271000,山东省泰安市中心医院病理科 |
| |
| 摘 要： | 目的 探讨环氧化酶-2(COX-2)表达和口腔鳞癌血管生成的关系.方法 免疫组化检测口腔鳞癌COX-2、诱导型一氧化氮合酶(iNOS)、血管内皮生长因子(VEGF)表达,并测定肿瘤微血管密度(MVD).结果 口腔鳞癌COX-2表达与VEGF、iNOS表达密切相关(P＜0.05).口腔鳞癌COX-2表达阳性组和阴性组MVD有显著差异(P＜0.01)结论 口腔鳞癌COX-2表达和肿瘤血管生成有关,iNOS 和VEGF可能参与COX-2对肿瘤血管生成的促进作用.
|
| 关 键 词： | 口腔鳞癌 环氧化酶 血管生成 血管内皮生长因子 诱导型一氧化氮合酶 |
| 文章编号： | 1006-673X（2006）03-0164-03 |
| 收稿时间： | 2005-06-13 |
| 修稿时间： | 2005年6月13日 |
COX-2 expression and angiogenesis in oral squamous cell carcinom |
| |
| LI Xiao-guang,GAO De-an,ZHANG Li,WANG Yan-xiu,YANG Xian-yong,WANG Qing.COX-2 expression and angiogenesis in oral squamous cell carcinom[J].Beijing Journal Of Stomatology,2006,14(3):164-166. |
| |
| Authors: | LI Xiao-guang GAO De-an ZHANG Li WANG Yan-xiu YANG Xian-yong WANG Qing |
| |
| Abstract: | Objective To explore the relationship between COX-2 expression and angiogenesis in oral squamous cell carcinoma. Methods The expression of COX-2,iNOS,VEGF and MVD were evaluated by immunohistochemistry. Results There was significant difference of MVD between COX-2 postive oral squamous cell carcinom and COX-2 negative one(P<0. 01).The expression of COX-2,iNOS and VEGF in oral squamous cell carcinoma was closely correlated. Conclusion The present findings suggest that there may be some link between COX-2 and angiogenesis in oral squamous cell carcinom,partly attributing to the effect of VEGF and iNOS. |
| |
| Keywords: | Oral squamous cell carcinoma Cyclooxygenase Angiogenesis Vascular endothelial cell growth factor Inducible nitric oxide synthase |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
