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The hand-foot-genital syndrome: on the variable expression in affected males |
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| Authors: | J P Fryns A Vogels P Decock H van den Berghe |
| Institution: | Centre for Human Genetics, University of Leuven, Belgium;Department of Paediatrics, University of Leuven, Belgium |
| Abstract: | Fryns JP, Vogels A, Decock P, Van den Berghe H. The hand-foot-genital syndrome: on the variable expression in affected males. Clin Genet 1993: 43: 232–234. © Munksgaard, 1993 In this report we document male-to-male transmission in the hand-foot-genital syndrome. An affected father transmitted the syndrome to his three sons. A grade IV hypospadias, which was the most severe genital anomaly in affected males, was present in the youngest, moderately mentally retarded microcephalic male sibling. |
| Keywords: | autosomal dominant inheritance hand-foot-genital syndrome hypospadias |