| 月桂氮酮对氟康唑角膜渗透性的影响 |
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| 引用本文： | 徐维平,陈礼明,胡葆诚,吴章友,程鹏. 月桂氮酮对氟康唑角膜渗透性的影响[J]. 中国医院药学杂志, 1997, 0(12) |
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| 作者姓名： | 徐维平 陈礼明 胡葆诚 吴章友 程鹏 |
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| 作者单位： | 安徽省立医院!合肥，230001，安徽省立医院!合肥，230001，安徽省立医院!合肥，230001，安徽省立医院!合肥，230001，安徽省立医院!合肥，230001 |
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| 摘 要： | 用高效液相色谱法测定免眼房水中氟康唑的浓度，来研究月桂氮酮对氟康唑角膜渗透性的影响。结果表明：用含0．02％，0．04％，0．08％和0．10％月桂氮酮的氟康唑滴眼液滴眼，能使兔眼房水中氟康唑的浓度分别增加2．5、3．5、4．0和4．2倍。提示月桂氮酮可提高氟康唑的疗效。
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| 关 键 词： | 月桂氮 酮 氟康唑 兔眼房水 |
Effects of laurocapram on corneal permeability of fluconazole |
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| Xu Weiping, Chen Liming, Hu Baocheng,et al. Effects of laurocapram on corneal permeability of fluconazole[J]. Chinese Journal of Hospital Pharmacy, 1997, 0(12) |
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| Authors: | Xu Weiping Chen Liming Hu Baocheng et al |
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| Abstract: | The concentration of fluconazole in rabbit aqueous humor was determined by HPLC to investigate the effects of laurocapram on comeal permeability of fluconazole. The results showed that different fluconazole eye drops administration containing 0. 02%, 0. 04 %, 0. 08 % and 0. 10% laurocapram could increase the concentration of fluconazole in rabbit aqueous humor in 2. 5, 3. 5,4. 0 and 4. 2 fold respectively. The results suggest that laurocapram can enhance the effect of fluconazole. |
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| Keywords: | laurocapram fluconazole aqueous humor |
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