26例胎儿先天性心脏畸形的产前诊断及临床分析 |
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引用本文: | 吴琦嫦,钟晓红,张爱格,周裕林,曾炳勋. 26例胎儿先天性心脏畸形的产前诊断及临床分析[J]. 中国优生与遗传杂志, 2009, 17(5): 114-116 |
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作者姓名: | 吴琦嫦 钟晓红 张爱格 周裕林 曾炳勋 |
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作者单位: | 厦门市妇幼保健院林巧雅妇儿医院产前诊断中心,福建,361000 |
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摘 要: | 目的了解胎儿先天性心脏畸形的类型,分析胎儿先天性心脏畸形合并心外畸形及染色体异常的发生率。方法回顾性分析产前超声发现胎儿先天性心脏畸形,且经过产前染色体检查及产后病理解剖证实的26例病例。结果发现10种类型的胎儿先天性心脏畸形,其中室间隔缺损的发生率最高,达57.2%,有4例单纯一种心脏畸形(15.4%),11例多发心脏畸形(42.3%),15例合并心外畸形(52.7%),12例合并染色体异常(46.2%)。结论胎儿期发现的先天性心脏畸形的类型一般较为严重,发生多种心脏畸形的机率较高,合并心外畸形和染色体异常的发生率也较高。
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关 键 词: | 先天性心脏畸形 胎儿 染色体 畸形 超声 尸体解剖 |
Prenatal diagnosis and clinical analysis about fetal congenital heart defects |
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Affiliation: | WU Qi - chang, ZHONG Xiao - hong, ZHANG Ai -ge, et al. (Center of Prenatal Diagnosis, Maternal and Child Health Care Hospital of Xiamen, Xiamen 361000, China) |
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Abstract: | Objective: To analyse the spectrum of congenital heart defects, the frequency of extracardiac malformations, and the proportion of chromosome aberrations among fetuses. Methods : Retrospective analysis 26 cases which were prenatally diagnosed fetal congenital heart defects by ultrasound and postnatally identified by necropsy, these fetal karyotype was prenatally performed. Results: 10 categories of congenital heart defects were identified, the incidence of ventricular septal defect was the highest (57.2%). In 4 cases the heart defect was isolated (15.4%), 11 cases were associated with additional cardiac malformations (42. 3% ), and chromosome anomalies were detected in 12 cases (46. 2% ). Conclusions: The type of fetal congenital heart defects are more serious. These defects are often associated with other cardiovascular and extracardiac malformations, as well as with chromosome anomalies. |
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Keywords: | Congenital heart defects Fetus Chromosome Malformation Ultrasound Necropsy |
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