脑梗塞患者非高密度脂蛋白胆固醇和C-反应蛋白与颈总动脉内中膜厚度关系研究

目的探讨脑梗塞患者非高密度脂蛋白胆固醇(non-HDL-C)和C反应蛋白(CRP)与颈总动脉内中膜厚度(IMT)的关系。方法选择207例脑梗塞患者与101例正常对照者;脑梗塞患者按其IMT分成三个亚组;根据是否存在颈总动脉硬化分为颈动脉硬化组和非颈动脉硬化组;测定甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、CRP,计算non-HDL-C值;将各组进行比较分析。结果与正常对照组相比较,脑梗塞组呈现出高TG、TC、non-HDL-C、LDL-C、低HDL-C及CRP水平明显升高;脑梗塞患者不同IMT水平组的non-HDL-C、CRP等有显著性差异,并随着IMT的增加而升高;颈动脉硬化组的non-HDL-c、CRP水平明显高于非颈动脉硬化组;non-HDL-C、CRP与IMT呈正相关。结论non-HDL-C和CRP可作为反映颈动脉硬化发生和脑梗塞危险性的指标。

Study on Correlation of Non-high Density Lipoprotein Cholesterol and C-reactive Protein with Carotid Artery Intima Media Thickness in Patients with Cerebral Infarction

Objective To investigate correlation of non-high density lipoprotein cholesterol(non-HDL-C) and C-reactive protein(CRP) with carotid artery intima media thickness(IMT) in patients with cerebral infarction.Methods The levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),and CRP were determined in 207 patients with cerebral infarction and in 101 healthy individuals as normal control group.The patients with cerebral infarction were divided into carotid arteriosclerosis group and non-carotid arteriosclerosis group according to IMT of carotid artery.The difference was analyzed in these groups,and the correlation of non-HDL-C and CRP with IMT of carotid artery was analyzed.Results The levels of TG,TC,non-HDL-C,LDL-C,HDL-C and CRP increased significantly in patients with cerebral infarction.There was significant difference of the levels of non-HDL-C and CRP in different IMT groups,and the levels of non-HDL-C and CRP increased with IMT.The levels of non-HDL-C and CRP increased significantly in cerebral infarction patients with carotid arteriosclerosis.Positive correlation was observed between non-HDL-C as well as CRP and IMT.Conclusions Non-HDL-C and CRP are two important indexes for predicting carotid arteriosclerosis and cerebral infarction.