成人获得性噬血细胞综合症肝功能损害临床资料分析 |
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引用本文: | 郭尚囡,李玉富,周健,刘新建,林全德,杜建伟,周可树,宋永平. 成人获得性噬血细胞综合症肝功能损害临床资料分析[J]. 医药论坛杂志, 2013, 0(2): 1-4 |
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作者姓名: | 郭尚囡 李玉富 周健 刘新建 林全德 杜建伟 周可树 宋永平 |
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作者单位: | [1]郑州大学附属肿瘤医院,郑州450008 [2]河南省肿瘤医院血液科,郑州450008 |
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摘 要: | 目的探讨成人获得性噬血细胞综合症(hemophagocyticsyndrome,HPS)肝功能损害的临床特点。方法回顾性分析郑州大学附属肿瘤医院2010年3月-2012年8月收治的24例成人获得性嗜血细胞综合症合并肝功能损害的患者,了解肝功能损害的特点,以及肝功能损害与获得性HPS病因和预后之间的关系。结果获得性HPS患者肝功能损害的特点为乳酸脱氢酶(LDH)及门冬氨酸转氨酶(AST)升高、低蛋白血症、高脂血症和黄疸。肿瘤继发HPS组乳酸脱氢酶(LDH)水平明显高于非肿瘤继发HPS组(P〈0.05)。门冬氨酸转氨酶(AST)增高、白蛋白(ALB)降低提示预后不良(P〈0.05)。24例患者中12周内共死亡15例,占62.50%。结论肝功能损害是获得性HPS常见的器官功能损害,其肝功能损害程度可能与获得性HPS的病因和预后相关。
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关 键 词: | 肝功能损害 噬血细胞综合症 乳酸脱氢酶 门冬氨酸转氨酶 白蛋白 |
Clinical analysis of adult acquired hemophagocytic syndrome patients with hepatic dysfunction 24 Cases |
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Affiliation: | GUO Shang - nan , LI Yu - fu, ZHOU Jian, LIU Xin - jian, LIN Quan - de, DU Jian - wei,ZHOU Ke - shu, SONG Yong - ping Tumor Hospital Affiliated to Zhengzhou University, Zhengzhou 450008, China |
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Abstract: | Objective To investigate the clinical features of acquired hemophagocytic syndrome(HPS) complicated with hepatic dysfunction. Methods Retrospective analysis of 24 cases of adult hemophagocytic syndrome with hepatic dys- function who received treatment in our hospital between March. 2010 and Aug. 2012. The characteristics of hepatic dys- function, the relationship between hepatic dysfunction and the cause, as well as prognosis of the acquired HPS were pre- lim inarily analysed. Results The characteristics of hepatic dysfunction in acquired HPS patients were hypoproteine- mia, hyperlipidemia, jaundice and increase of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) lev- els. The level of LDH in the malignancy associated hemophagocytic lymphohistioeytosis group were higher than that in non - malignancy associated hemophagocytic lymphohistiocytosis group ( P 〈 0. 05 ). And the increase of AST levels or the reduce of albumin (ALB) indicated poor prognosis ( P 〈 0.05 ). Conclusions Liver damage is a common organ functional disorder in patients with acquired HPS , which may be correlated to the cause and the prognosis of acquired HPS. |
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Keywords: | Hepatic dysfunction Hemophagocytic syndrome Lactate dehydrogenase Aspartate aminotransferase Albumin |
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