米非司酮与甲睾酮治疗围绝经期子宫肌瘤观察

目的观察甲睾酮联合米非司酮治疗围绝经期子宫肌瘤的临床疗效。方法将60例围绝经期子宫肌瘤患者随机分为治疗组和对照组，每组30例，治疗组给予口服甲睾酮和米非司酮治疗，对照组仅给予口服米非司酮治疗。3个月为1个疗程，连服2个疗程后评价临床疗效。结果治疗组临床总有效率为96．7％，高于对照组的80．O％（P〈0．05）；两组治疗后子宫和子宫肌瘤的体积均较治疗前小（P〈0．05）；治疗组在诱导绝经和缩瘤比例方面优于对照组（P〈0．05）。结论甲睾酮联合米非司酮能有效治疗围绝经期子宫肌瘤。

Clinical observation on Mifepristone and Methyltestosterone in treatment of uterine myoma during perimenopause

Objective To investigate the curative effect of mifepristone and methyltestosterone in the treatment of uterine myoma during perimenopause. Methods All the 60 patients uterine myoma during perimenopause were divided into two groups randomly. The 30 patients in the treatment group were treated with mifepristone and methyltestosterone;The other 30 patients in the control group were treated with mifepristone only. For the two groups, 3 months was one course of treatment. The curative effect was evaluated after two courses of treatment. Results The total response rate （96. 7% ） in the treatment group was higher than that （ 80. 0% ） in the control group （ P 〈 0. 05 ） ; The volumes of uterus and uter- ine myoma after the treatment were smaller than those before the treatment （ P 〈 0.05 ） ; The treatment group was better than the control group in the induction of menopause and the shrink of tumors （P 〈 0. 05）. Conclusions Mifepristone and methyltestosterone is effect for uterine myoma during perimenopause.