中国山东沿海地区汉族男性人群白介素-23受体基因多态性与痛风的易感性研究

目的探讨中国山东省沿海地区汉族男性群体的白细胞介素23受体（IL-23R）基因rs7517847位点G／T的多态性是否与痛风的易感性有关。方法选取202例痛风患者和346例健康对照者，检测中国汉族男性群体的IL-23受体内含子区rs7517847位点基因多态性分布，数据经，检验得出其与痛风发病的遗传易感性的关系。结果经，检验，痛风组和对照组中IL-23R基因rs7517847位点GG，GT和1Tr基因型频率（10．4％，49．5％，40．1％；16．2％，49．7％，34．1％；X^2=4．305，P〉0．05）与等位基因频率G和T（35．1％，41％；64．9％，59％；X^2=3．727，P〉0．05）均无统计学意义。IL-23R基因rs7517847位点G／T基因多态性与痛风病的危险因素无显著性关联。结论尚不能认为中国沿海地区汉族男性人群中IL-23R内含子区rs7517847位点基因多态性与痛风有关联性。

Relationship between interleukin -23 reporter polymorphism and susceptibility to gout in Chinese male population

Objective： To explore gene polymorphism of the G/T genotype of rs7517847 in the intron of IL - 23R gene in male population living in the coaslal area of Shandong, and thus to investigate the relationship between the gene polymorphism of IL- 23R and gout. Methods： A total of 202 gout patients and 346 healthy controls were enrolled. The possible association between thepolymor- phism of IL- 23R and gout in Chinese was investigated and genotype frequencies and allelic frequencies were calculated by Fluores- cence quantitative PCR Taqman probe technology. Comparisons bctween the groups were performed with X2 test. Results： The fre- quences of GG. GT and TY genotypes were 10.4%, 49. 5% and 40. 1%, respectively among gout patients, while they were 16. 2%, 49. 7% and 54. 1%, respectively among the controls. There was no ststistically difference in IL -23R （G/T） genotype fre- quencies between gout paitents and controls （X2 = 4. 305, P 〉 0. 05）. The allele frenquencies of G and T in gout cases were different from those in the controls （35. 1%, 41% ; 64. 9%, 59% ; X2 = 3. 727, P 〉 0. 05）. In all, no association between IL- 23R （G/T） genotypes and risk factors for gout were observed in gout cases by X2 test. Conclusion： Results of the present study suggest that the G/T genotype of rs7517847 in the intron of IL -23R gene is not associated with gout in male population living in the coastal area of shandong.