PTEN和NDRG1在子宫内膜癌中的表达及意义

目的探讨PTEN和NDRG1蛋白的异常表达在子宫内膜癌发生、侵袭和转移中的作用及意义。方法采用免疫组织化学方法检测124例I型子宫内膜癌、28例内膜不典型增生、35例正常内膜组织中PTEN和NDRG1的表达，结合临床病理因素进行分析。结果PTEN和NDRG1在子宫内膜癌中的阳性表达率分别为29．18％、52．14％，与正常内膜组和不典型增生组比较，差异均有统计学意义（P〈0．05）。PTEN表达下调或NDRG1过度表达与肿瘤分化程度明显相关（P〈0．05）。结论PTEN的表达缺失或NDRG1蛋白的高表达，在子宫内膜癌发生、侵袭和转移中起重要作用，故而在临床中检测PTEN和NDRG1的表达，对于判断子宫内膜癌的恶性程度和预后有重要意义。

Expression and significance of PTEN and NDRG1 in endometrial carcinoma.

Objective： To investigate the role of aberrant expression of PTEN and NDRG1 protein in the pathogenesis and progression of endometrioid carcinoma. Methods： Immunohistochemical staining were employed to detect the expression of PTEN and NDRG1 in tissues of type I endometrial carcinoma （n=124） and atypical hyperplasia （n=28） and normal endometrial tissues （n=35） . The relationship among the markers, as well as their correlations with clinicopathological features were evaluated. Results： The expression of PTEN and NDRG1 in tissues of endometrioid carcinoma was 29.18% and 52.14%, respectively, and was significantly different from that in tissues of atypical hyperplasia and normal endometrial tissues （P〈0.05） . The downregulation of expression of PTEN and overexpression of NDRG1 were significantly related to the tumor differentiation （P 〈0.05） . The expression of PTEN was negatively related to that of NDRG1 in tissues of endometrioid carcinoma （P〈0.05） . Conclusion： The absence of PTEN may up regulate the expression of NDRG1 protein, which may be involved in the pathogenesis and progression of endometrioid carcinoma, and the combined detection of these markers is of great value in the prediction of tumor behavior and prognosis.