卵巢局部IGF-I系统与多囊卵巢综合征胰岛素抵抗的相关性研究 |
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引用本文: | 李晓林,;毕淑娜,;孙颖,;孙宝治,;范俊,;孟莉,;袁文娟. 卵巢局部IGF-I系统与多囊卵巢综合征胰岛素抵抗的相关性研究[J]. 中国优生与遗传杂志, 2014, 0(6): 17-19 |
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作者姓名: | 李晓林, 毕淑娜, 孙颖, 孙宝治, 范俊, 孟莉, 袁文娟 |
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作者单位: | [1]青岛大学医学院附属青岛市市立医院东院区妇科,青岛266071; [2]山东省青岛市市南区妇幼保健所,青岛266071; [3]山东省青岛市第五人民医院妇科,青岛266021 |
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摘 要: | 目的:研究卵巢局部胰岛素样生长因子-I系统(IGF-I系统)在伴有胰岛素抵抗多囊卵巢综合征中的作用机制。方法选择30例合并胰岛素抵抗的PCOS(polycystic ovary syndrome)患者为试验组,30例患有卵巢良性肿瘤需手术探查的患者为对照组。检测并对比血清、小卵泡液中IGF-I、胰岛素样生长因子结合球蛋白-1(IGFBP-1)与各项性激素,FI,2hI,ISI,QUICK I,卵巢超声指标,研究其与各种指标间的相关性。结果试验组小卵泡液IGF-I高于对照组(P〈0.01),小卵泡液及血清IGFBP-1低于对照组(P〈0.05,P〈0.01)。试验组小卵泡液IGF-I水平高于血清(P〈0.01),小卵泡液IGFBP-1水平低于血清(P〈0.05)。试验组小卵泡液IGF-I与T0、E2及卵巢体积(OV),卵巢总面积(TA),卵泡数(FN),空腹胰岛素(FI),服糖后2h胰岛素(2hI)呈正相关(P〈0.05);血清IGF-I与胰岛素敏感指数(ISI),体重指数(BMI),腰臀比(WHR)呈正相关(P〈0.05),与定量胰岛素敏感指数(QUICK I)呈负相关(P〈0.05);试验组小卵泡液及血清IGFBP-1与FI,2hI呈负相关(P〈0.05)。结论 IR可能通过影响卵巢局部IGF-I系统,刺激卵巢分泌雄激素,引发排卵障碍,在PCOS的发病机制中起到重要作用。
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关 键 词: | 多囊卵巢综合征 胰岛素抵抗 胰岛素样生长因子-I 胰岛素样生长因子结合球蛋白-1 |
Study of the relationship between the IGF-I system in ovary and the polycystic ovary syndrome combined withinsulin resistanceI |
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Affiliation: | LI Xiao-lin, BI Shu-na, SUN Ying, et al. (Department of Gynecology, The Affiliated Qingdao Municipal Hospital East Area of Qingdao University Medical Collage Qingdao 266071 ) |
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Abstract: | Objective:To study effects of ovarian insulin-like growth factor-I(IGF-I)system on PCOS with insulin resistance(IR). Methods:30 insulin-resistant PCOS patients and 30 patients with gynecology benign disease were enrolled. IGF-I and insulin-like growth factor binding protein-1(IGFBP-1)in follicular fluid and serum,reproductive hormones,insulin sensitivity indexs,ovarian ultrasound parameters were measured and compared between two groups.Correlation of IGF-I system with other parameters were analysed. Results:Follicular fluid IGF-I in PCOS group was significantly lower than in control group(P0.01). Both serum and follicular fluid level of IGFBP-1 in PCOS group were all markedly lower than in control group(P0.05,P0.01). In PCOS group,IGF-I in follicular fluid was significantly higher than in serum(P0.01),and IGFBP-1 in follicular fluid was significantly lower than in serum(P0.05).In PCOS group,follicular fluid IGF-I positively correlated with T0,E2,ovary volume(OV),total area(TA),follicle number(FN),free insulin(FI),2hI(P0.05). Serum IGF-I positively correlated with insulin sensitivity index(ISI),body mass index(BMI),waist/hip ratio(WHR)(P0.05),negatively correlated with QUICK I(P0.05).Both follicular fluid and serum IGFBP-1 negatively correlated with FINS,2hI(P0.05). Conclusion:These results raise the possibility that IR likely contributes to hyperandrogenism and anovulatiaon in PCOS by effecting ovarian IGF-I system. |
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Keywords: | Polycystic ovary syndrome (PCOS) Insulin resistance (IR) Insulin-like Growth Factor I (IGF-I)Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) |
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