厦门地区不同职业对男性不育患者精子DNA完整性和精子参数的影响

目的探讨厦门地区不同职业对精子DNA完整性和精子参数的影响。方法将就诊的1509例男性不育患者按照职业分为司机组、计算机工作者组、工人组。将600例正常生育组做为健康对照组。采用SQA—V全自动精子分析仪进行精液常规分析，精子DNA完整性检测采用精子染色质扩散试验（SCD），以DNA断裂指数（DFI）表示。结果司机组、计算机工作者，工人组的精子密度、活动率、前向运动率和DFI与对照组比较差异有统计学意义（P〈0．05）；司机组和计算机工作者组的精子活动率、前向运动率、精子密度及和DFI与工人组比较差异有统计学意义（P〈0．05）；4组的精液量、精液pH值差异无统计学意义（P〉0．05）。结论司机、计算机工作者和工人可以影响精液质量，从而导致男性不育。

Influence of different occupations on male infertility patients of sperm DNA integrity and sperm parameters in Xiamenarea.

Objectives： To explore the effect of different occupations on male sperm DNA integrity and sperm parameters. Methods： 1509 cases of male infertility patients will be divided into drivers, computermen and workers of 3 teams, 600 control cases were recruited for the study; sperm parameters were analysised by fully automated SQA-V sperm analyzer; Sperm DNA integrity was evaluated by sperm chromatin dispersion （SCD） , and the results were expressed interms of DNA fragmentation index （DFI） . Results： A significant difference in the concentration and mobility and forward mobility and DFI of sperm between 4 teams （P〈0.05） . A difference in the concentration and mobility and forward mobility and DFI of sperm between drivers, computermen and workers （P〈0.05） . But there is no difference in the semen volume and pH between 4 teams （P〉0.05） . Conclusion： Drivers and computermen affect routine semen parameters and soerm DNA intezritv and result in m ale infertility.