| 神经管缺陷与Dishevelled基因表达的关系 |
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| 引用本文： | 杨新,寇莹,扈雪晗,付四清. 神经管缺陷与Dishevelled基因表达的关系[J]. 中国优生与遗传杂志, 2014, 0(1): 5-7 |
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| 作者姓名： | 杨新 寇莹 扈雪晗 付四清 |
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| 作者单位： | [1]华中科技大学同济医学院附属协和医院第一临床学院,武汉430030 [2]华中科技大学同济医学院遗传学系,武汉430030 |
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| 基金项目： | 大学生创新性实验计划项目[13A266] |
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| 摘 要： | 神经管缺陷是复杂的多基因疾病,是中枢神经系统最常见的先天畸形。虽然其发病机制尚不清楚,但是研究已证实遗传因素与其发病具有相关性。本文将着重对Dishevelled基因细胞信号通路在神经管发育、神经管缺陷发病机制中的作用及有关Dishevelled基因的研究进展进行阐述。
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| 关 键 词： | 神经管缺陷 Dishevelled基因 平面细胞极性通路 |
The relationship between neural tube defects and Dishevelled genes expression |
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| Affiliation: | YANG Xin, KOU Ying, HU Xue - han , FU Si - qing( 1. Department of the First Clinical College, Tongji Medical School of Huazhong University of Science and Technology, Wuhan 430030, China; 2. Department of Medical Genetics, Tonal Medical School of Huazhong University of Science and Technology, Wuhan 430030, China) |
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| Abstract: | Neural tube defects are complex multi - gene disease and the most common congenital defect of the central nervous sys-tem （CNS）. Although the pathogenesis is not so clear, the association between genetic factors and the disease has already been con-firmed. This paper reviews the functions of Dishevelled genes in neural tube development and possible mechanisms of neural tube dis-ease, concluding the current progresses in Dishevelled genes. |
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| Keywords: | Neural tube defects Dishevelled genes Planar cell polarity pathway |
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