神经干细胞的增殖与分化调控机制

神经干细胞(NSC)是具有高度自我更新能力并能分化为神经元、星形胶质细胞和少突胶质细胞的神经前体细胞。从胚胎和成年哺乳动物脑内均可分离出NSC。干细胞的增殖和分化受微环境和基因的双重调控,现已发现多种细胞因子和基因可调节NSC的增殖并决定其分化方向。对NSC增殖和分化机制认识的加深将会促进NSC的临床应用。

Modulating Mechanisms of Proliferation and Differentiation of Neural Stem Cells

Neural stem cells (NSCs) have the ability of highly self-renewal and can be differentiated into neurons, astrocytes and oligodendrocytes. NSCs can be isolated from the brains of embryonic and adult mammals. The proliferation and differentiation of stem cells are regulated by both microenvironmental factors and genes. It has been found that a number of cytokines and genes can regulate the proliferation of NSCs, and determine their direction of differentiation. Further understanding of the mechanisms of proliferation and differentiation of NSCs will significantly promote the clinical application of NSCs.