糖尿病患者血清ICA、IAA、GAD-Ab、IA-2-Ab的检测及临床意义

目的：探讨ICA、IAA、GAD—Ab、IA-2-Ab对糖尿病患者的检测及临床意义。方法：用ELISA法测定155例1型糖尿病患者和44例2型糖尿病患者以及32例正常人血清中的ICA、IAA、GAD—Ab、IA-2抗体。结果：1型糖尿病组和2型糖尿病组ICA的阳性率分别为36．8％和11．4％，IAA的阳性率分别为23．2％和16．0％，GAD—Ab的阳性率分别为58．7％和16．0％，IA-2-Ab的阳性率分别为20．0％和6．8％。结论：ICA、IAA、GAD—Ab、IA-2抗体对1型糖尿病的早期诊断及预测有重要的临床意义，且联合测定以上抗体能提高检出率，避免漏诊。

Detection and Clinical Significance of ICA,IAA,GAD-Ab and IA-2-Ab in Serum of Diabetes Mellitus

Objective To inquire into the positive rate and clinical significance of islet cell antibody(ICA),insulin autoantibody(IAA),glutamic acid decarboxylase antibody(GAD-Ab) and IA-2 antibody in diabetes mellitus.Methods 155 patients who were diagnosed as type 1 diabetes mellitus(1-DM) and 44 patients who were diagnosed as type 2 diabetes mellitus (2-DM) were measured with ELISA.Results In 1-DM and 2-DM groups,the positive rates of ICA detected were 36.8% and 11.4%;the positive rates of IAA detected were 23.2% and 16.0%;the positive rates of GAD-Ab detected were 58.7% and 16.0%,the positive rates of IA-2-Ab detected were 20.0% and 6.8%.Conclusion The detection of ICA,IAA,GAD-Ab and IA-2 antiboby in serum have the important clinical significane in early diagnosis and forecast of 1-DM,and combined detection of these antibody can improve percentages of positive and avoid missed diagnosis.