慢性牙周炎患者血清生化指标分析

目的通过分析牙周炎患者和牙周健康者的血糖、血脂、血清钙水平,探讨血清生化指标的异常是否对牙周炎的发生发展起促进作用。方法研究对象225人均无全身系统性疾病,病例组为慢性牙周炎患者145人,以临床附着丧失（CAL）<3 mm或CAL≥3 mm分为轻度组和中、重度组,对照组为牙周健康者80人,空腹抽取静脉血,检测血糖、血脂和血清钙水平,用SPSS 12.0统计软件包对血清学指标进行统计分析。结果病例组和对照组血脂和血清钙水平无显著差异（P>0.05）,病例组血糖、低密度脂蛋白高于临界值者和高密度脂蛋白、血清钙低于临界值者比例明显高于对照组（P<0.05）,轻度组血糖、甘油三酯、低密度脂蛋白水平明显低于中、重度组（P<0.05。结论血糖、血脂升高,血清钙降低可能增加宿主对牙周炎的易感性和促进牙周炎的发展。

Study of serological biochemistry index of chronic periodontitis

Objective To investigate the effect of serum biochemistry on the development of periodontitis. Methods 225 participants without any system disease were involved in the study. Case group consist of 145 chronic peri-odontitis and was divided into gentle group （clinical attachment loss<3 mm）, moderate and severe group（clinical attachment loss≥3 mm）. Control groupconsist of 80 periodontal healthy persons. Peripheral blood sample was obtained from each subject by venipuncture. Serum chemistry variables including glucose, lipid and calcium were analyzed. SPSS 12.0 software package was adopted to analyze the investigation results. Results There’s no statistically significant difference of serum, lipid and calcium between case group and control group（P>0.05）. But case group had a higher percentage of people with abnormal glucose, lipid and calcium than control group（P<0.05）. Moderate and severe group had a significantly higher serum glucose, triglyceride and lipoproteins-cholesterol than gentle group（P<0.05）. Conclusion Abnormal level of serum glucose, lipid and calcium may increase the affectability of host to periodontitis and promote the inflammation in paradentium.