Effect of social isolation on corticosterone secretion elicited by histaminergic stimulation |
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Authors: | Gą dek-Michalska,A.,Borycz,J.,Bugajski,J. |
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Affiliation: | 1.Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna St., PL-31-343, Kraków, Poland ; |
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Abstract: | Social stress of crowding for 3, 7, 14 and 21 days drastically reduces the serum corticosterone response to intracerebroventricular administration of dimaprit, a histamine H2-receptor agonist, moderately diminishes the response to pyridylethylamine, an H1-receptor agonist, and does not change significantly the corticosterone response to histamine. These results suggest that social stress of crowding considerably desensitizes central histamine H2-receptors involved in stimulation of the hypothalamic-pituitary-adrenal axis. |
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