2014年老年病房内铜绿假单胞菌感染状况及其耐药性分析

目的 分析老年病房内铜绿假单胞菌的感染状况及耐药情况。方法 收集2014年1~12月安徽省立医院老年内分泌科临床感染患者的痰、尿或血标本，采用法国梅里埃公司的VITEK2 Compact进行细菌鉴定及药敏实验。结果 共检出63株细菌，其中铜绿假单胞菌共29株，占46.03%。29株铜绿假单胞菌中，痰培养阳性26株（89.66%），尿培养阳性3株（10.34%）。多重耐药的铜绿假单胞菌16株，占55.17%，耐药率低于10%的药物有阿米卡星、庆大霉素和妥布霉素，耐药率超过80%的有哌拉西林、头孢唑林、头孢曲松、头孢替坦、复方新诺明和呋喃妥因，对亚胺培南的耐药率为13.79%。结论 老年患者是铜绿假单胞菌的易感人群，临床多表现为肺部感染，细菌耐药率高。

Analysis of infection situation and drug resistance of Pseudomonas aeruginosa isolated from Department of Geriatrics in 2014

Objective To investigate theinfection situation and drug resistance of Pseudomonas aeruginosa in Department of Geriatricsin a hospital.Methods Sputum, urine, and blood samples were collected during the year of 2014. The bacteria identification and drug sensitivity analysis were done by using VITEK 2 compact.Results There were 29 Pseudomonas aeruginosa cases from sputum and urine samples detected in 63 bacteria cases with the detecting rate of 46.03%; 26 (89.66%) cases were from sputum samples whereas 3(10.34%) cases were from urine. Among all detected Pseudomonas aeruginosa cases, 16(55.17%) of them were multi-resistant. Drugs with resistance rate less than 10% were Amikacin, gentamicin and tobramycin; drugs with resistance rate higher than 80% were piperacillin, cefazolin, ceftriaxone, cefotetan, cotrimoxazole, and nitrofurantoin, and the resistance rate of imipenem was 13.79%.Conclusion Elderly patients are susceptible to Pseudomonas aeruginosa infection with clinical manifestation of pneumonia anda high rate of antibiotics resistance.