第二线粒体源性胱氨酸酶激活因子及其类似物与肿瘤的相关性研究进展

第二线粒体源性胱氨酸酶激活因子(Smac)是一种存在线粒体中并具有促凋亡作用的蛋白,Smac主要通过参与细胞凋亡的线粒体途径和死亡受体途径的下游反应,特异性地与凋亡抑制因子(IAPs)结合,解除IAPs对Caspase的抑制效应从而促进细胞凋亡。在肿瘤细胞中,Smac的过表达可以抑制或延缓肿瘤的发生发展过程,提高细胞浆Smac含量可增强细胞对放化疗的敏感性。人工合成的Smac类似物可通过级联放大效应提高肿瘤细胞对放化疗的敏感性,具有高效、低毒、高通透性等优点,为肿瘤的治疗提供了新的方法和思路,具有重要的临床意义。该研究就Smac、Smac类似物与肿瘤的相关性研究进展做一综述。

Advances in the research of the relationship between Smac,Smac mimetic and tumor

Smac is a newly found protein promoting apoptosis of mitochondria,which can promote cell apoptosis and was initially discovered independently by two groups in 2000.Smac has a pro-apoptotic effect that is mediated by its interaction with IAPs and the release of caspases from them.Overexpression of Smac in cancer cells can promote its cells apoptosis and postpone its development.Improving content of Smac in the cytoplasm can sensitize these cells to chemotherapy and radiotherapy.Smac mimetics is a potent enhancer of chemotherapy and radiotherapy,which can overcome the resistance of several cancers to anti-cancer therapies and have the advantages of high efficiency,low toxicity and high permeability.It is clear that Smas has great therapeutic potential for the treatment of cancer and has important clinical significance.In this article,we reviewed the recent advances in the study of the correlation among Smac,Smac mimetic and cancer.