| 醛固酮合成酶基因多态性与高血压病相关性研究 |
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| 引用本文： | 张文秀,陈爱华,钱学贤,唐晓明,陆青.醛固酮合成酶基因多态性与高血压病相关性研究[J].总装备部医学学报,2003(4). |
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| 作者姓名： | 张文秀 陈爱华 钱学贤 唐晓明 陆青 |
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| 作者单位： | 解放军第546医院，第一军医大学珠江医院，第一军医大学珠江医院，第一军医大学珠江医院，第一军医大学珠江医院 新疆马兰841700 |
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| 摘 要： | 本研究旨在观察我国华南地区汉族人群醛固酮合成酶 (CYP1 1B2 )基因 344C/T多态性与高血压病 (EH)相关性。 方法 以 1 36例原发性高血压病 (EH组 )和 1 1 0例健康查体者 (对照组 )为对象 ,测定相关临床指标 ;应用多聚酶链式反应 (PCR)、限制性内切酶方法检测CYP1 1B2 基因的多态性分布。 结果 EH组CYP1 1B2 基因 334C/T多态性与对照组比较基因型和等位基因分布均无显著性差异。 结论 CYP1 1B2 基因 344C/T多态性与我国华南地区汉族人群的EH发生无相关性
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| 关 键 词： | 醛固酮合成酶 基因多态性 原发性高血压病 |
Relationship between gene polymorphism of aldosterone synthase and essential hypertension |
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| ZHANG Wenxiu,CHEN Aihua,QIAN Xuexian,et al..Relationship between gene polymorphism of aldosterone synthase and essential hypertension[J].Medical Journal of Central Equipment Headquarters,2003(4). |
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| Authors: | ZHANG Wenxiu CHEN Aihua QIAN Xuexian |
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| Institution: | ZHANG Wenxiu,CHEN Aihua,QIAN Xuexian,et al. 546 Hospital of PLA,Xinjiang 841700,China |
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| Abstract: | To investigate the relationship between gene polymorphism of aldosterone synthase (CYP11B2) and essential hypertension EH. Methods 1. Clinical indexes were measured in 136 patients with EH and 110 controls. 2. DNA was extracted from peripheral blood leukocytes. 3. The 344C/T polymorphism of CYP11B2 gene was monitored by PCR and HaeIII restriction endonuclease digestion methods. Results The analysis of individual genotypes of CYP11B2 gene showed no significant difference in genotype or allele frequencies distribution on EH compared with controls. Conclusion There may be no association between the polymorphism of CYP11B2 gene and essntial hyptension. |
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| Keywords: | Essential hypertension Aldosterone synthase Gene polymorphism |
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