An Overview of the Role of Radiotherapy in the Treatment of Small Cell Lung Cancer – A Mainstay of Treatment or a Modality in Decline? |
| |
| Institution: | 1. Icon Cancer Centre, Concord Repatriation General Hospital, Concord, NSW, Australia;2. South West Sydney Clinical Campuses, University of NSW, Liverpool, NSW, Australia;3. Sydney West Radiation Oncology Network (SWRON), Sydney, NSW, Australia;4. Sydney Medical School, Westmead Hospital, University of Sydney, Sydney, NSW, Australia;5. The Westmead Institute for Medical Research (WIMR), Westmead, NSW, Australia;7. Cancer Therapy Centre, Liverpool Hospital, Liverpool, NSW, Australia;11. Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia;1. Northern Ireland Cancer Centre, Belfast City Hospital, Belfast, UK;2. University Hospitals Sussex NHS Foundation Trust, West Sussex, UK;1. Department of Nuclear Medicine, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey;2. Department of Nuclear Medicine, Gazi University Faculty of Medicine, Ankara, Turkey;3. Department of General Surgery, Gazi University Faculty of Medicine, Ankara, Turkey;4. Department of Internal Medicine, Division of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey;5. Department of Pathology, Gazi University Faculty of Medicine, Ankara, Turkey;1. Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;2. Department of Cardiothoracic Surgery, The Royal Melbourne Hospital, Melbourne, Victoria, Australia;3. School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia;4. Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia;5. Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia |
| |
| Abstract: | AimsSmall cell lung cancer (SCLC) accounts for about 15% of all lung cancers. Chemotherapy, immunotherapy and radiotherapy all play important roles in the management of SCLC. The aim of this study was to provide a comprehensive overview of the role and evidence of radiotherapy in the cure and palliation of SCLC.Materials and methodsThe search strategy included a search of the PubMed database, hand searches, reference lists of relevant review articles and relevant published abstracts. ClinicalTrials.gov was also queried for relevant trials.ResultsThoracic radiotherapy improves overall survival in limited stage SCLC, but the timing and dose remain controversial. The role of thoracic radiotherapy in extensive stage SCLC with immunotherapy is the subject of several ongoing trials. Current evidence supports the use of prophylactic cranial irradiation (PCI) for limited stage SCLC but the evidence is equivocal in extensive stage SCLC. Whole brain radiotherapy is well established for the treatment of brain metastases but evidence is rapidly accumulating for the use of stereotactic radiosurgery. Further studies will define the role of PCI, whole brain radiotherapy and hippocampal avoidant PCI in the immunotherapy era.ConclusionRadiotherapy is an essential component in the multimodality management of SCLC. Technological advances have allowed safer delivery of radiotherapy with reduced toxicities. Discussion at multidisciplinary team meetings is important to ensure radiotherapy is considered and offered in appropriate patients. |
| |
| Keywords: | Extensive stage limited stage prophylactic cranial irradiation radiotherapy small cell lung cancer |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
