Association between visceral adiposity index and incident stroke: Data from the China Health and Retirement Longitudinal Study |
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| Affiliation: | 1. Department of Laboratory Medicine, China-Japan Union Hospital of Jilin University, Jilin University, Jilin, China;2. Imaging and Nuclear Medicine, China-Japan Union Hospital of Jilin University, Jilin University, Jilin, China;3. Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University, Jilin University, Jilin, China;4. Department of Nephrology, China-Japan Union Hospital of Jilin University, Jilin University, Jilin, China;5. Endoscopy Center, China-Japan Union Hospital of Jilin University, Jilin University, Jilin, China;1. Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Mexico;2. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Mexico;1. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy;2. Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy;3. Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Palermo, Italy;1. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan;2. Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Japan;1. Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning, PR China;2. Postgraduate Affairs Section, School of Public Health, China Medical University, Shenyang, Liaoning, PR China;3. School of Public Health, Tsinghua University, Beijing, PR China;1. Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia;2. Department of Kinesiology, University of Georgia, Athens, USA;3. The Nuffield Department of Women''s & Reproductive Health, University of Oxford, Oxford, UK;4. Murdoch Children''s Research Institute, Melbourne, Australia;5. Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia;6. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland;7. Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland |
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| Abstract: | Background and aimsVisceral adiposity index (VAI), an indicator of visceral fat, is associated with metabolic health and arterial stiffness. However, studies correlating VAI and stroke are limited. This study aimed to explore the association between VAI and incident stroke in the Chinese population.Methods and resultsWe retrospectively analysed the data of 9127 individuals enrolled in the China Health and Retirement Longitudinal Study. The first survey of the study was conducted during 2011–2012 and the individuals were followed up until Survey 4 (2017–2018). Multivariable-adjusted Cox regression models were used to evaluate the association between VAI and stroke. The mean age of the study population was 59.3 ± 9.5 years and 4938 (54.1%) participants were women. During the median follow-up of 5.2 [1.0–7.0] years, 833 (9.1%) participants developed stroke, and the cumulative incidence of stroke increased with increasing quartiles of VAI (8.6%, 8.7%, 9.2%, and 10.0%). Compared to those in the first quartile of VAI, individuals in the fourth quartile had an increased risk of stroke (adjusted hazard ratio, 1.45; 95% CI, 1.15–1.75). The results were stable in several sensitivity analyses.ConclusionOur findings suggest a positive association between VAI and incident stroke in the Chinese population. |
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| Keywords: | Visceral adiposity index Stroke Cohort study Risk factor Adiposity Primary prevention VAI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" visceral adiposity index CHARLS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" China Health and Retirement Longitudinal Study DALYs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" disability-adjusted life-years YLLs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" years of life lost BMI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" body mass index HDL-C" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" high-density lipoprotein cholesterol hs-CRP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" high-sensitivity C-reactive protein eGFR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" estimated glomerular filtration rate HR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" Hazard ratio CI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" confidence interval SD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," _" :" standard deviation JNK" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" c-Jun N-terminal kinase |
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