Abstract: | Abstract: Objective To analyze and evaluate the drug resistance of positive strains of acid-fast bacilli from January 1997 to April 2021 in the Fourth Hospital of Inner Mongolia Autonomous Region. Methods Using acid-fast bacteria culture and bacteria type identification plus drug sensitivity test method, gene chip drug resistance detection method, BACTEC MGIT960System960 acid-fast bacteria drug resistance detection method anti-tuberculosis drugs isoniazid, rifampicin, ethambutol, Pyrazinamide, prothionamide, levofloxacin, ofloxacin are tested for drug sensitivity to sodium aminosalicylate, prothionamide, capreomycin. Results 1612cases of acid-fast bacteria were cultured and drug-sensitive, and 5 cases of non-tuberculous mycobacteria were detected. The resistance rate of drug resistance detection from high to low was 30.6% for prothio-isonicotinamide, 26.7% for Rm, 17.3% for R, 14.6% for Sm, and 7.9% for multidrug resistance. The drug was 0.8%, which was the highest rate among men over 60 years old. 21 strains were cultured positive in 960, and 3 strains were resistant to pyrazinamide. The drug resistance rate was 1.4%. Conclusion 1 Prothionamide has a high drug resistance rate among patients admitted to our hospital, which suggests that our hospital should fully consider this factor in the formulation of future anti-tuberculosis treatment programs. 2 The existence of multidrug-resistant and extensively drug-resistant tuberculosis prompts us to attach importance to the standardized treatment of tuberculosis, evaluate the treatment effect at any time, and formulate a reasonable and effective anti-tuberculosis treatment plan. |