|
|||||
|
|
Association of childhood obesity phenotypes with early adulthood Carotid Intima-Media Thickness (CIMT): Tehran lipid and glucose study |
|
| Institution: | 1. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran;2. Imaging Department, Taleghani Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran;3. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran;4. Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran;1. Center for Advancing Population Science (CAPS), Medical College of Wisconsin, Milwaukee, WI, USA;2. Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA;1. Unit of Cardiovascular Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy;2. Unit of Food Science and Nutrition, Department of Science and Technology for Humans and the Environment, Campus Bio-Medico University of Rome, Rome, Italy;1. Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy;2. Emergency Medicine Department, AOU Maggiore della Carità, Novara, Italy;3. Division of General Medicine, Ospedale S. Giuseppe, I.R.C.C.S. Istituto Auxologico Italiano, Verbania, Italy;1. Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, South Korea;2. Institute for Health and Society, Hanyang University, Seoul, South Korea;3. Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea;4. Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, South Korea;5. Division of Epidemiology and Health Index, Center for Genome Science, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea;6. Department of Physiology, College of Medicine, Hanyang University, Seoul, South Korea;5. IRCCS Neuromed, Pozzilli and Università dell’Insubria, Varese, Italy;1. Department of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli, IS, Italy;2. Mediterranea Cardiocentro, Napoli, Italy;3. Neurosurgery Department, IRCCS NEUROMED, Pozzilli, IS, Italy;4. Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy |
| Abstract: | Background and aimsOver the past few years, obesity and metabolic syndrome prevalence among children and adolescence have an increasing trend. This study aims to investigate the association of obesity phenotypes during childhood and adolescence with early adulthood carotid intima-media thickness (CIMT).Methods and resultsParticipants were divided into four obesity phenotypes: Metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Participants were followed for 18 years. Multivariate-adjusted Risk Ratios (RRs) were calculated for high CIMT (≥95% percentile) incidence.In this cohort study 1220 children and adolescents with the average age of 10.9 ± 4.0 years were included. CIMT values had a significantly increasing trend from MHNW to MUO group (p for trend<0.001). Individuals with normal weight status, even with an unhealthy metabolic profile did not have higher risk of high CIMT. Similarly, Children with obesity but healthy metabolic status was not at higher risk. On the other hand, MUO phenotype during childhood was associated with increased risk of high CIMT in early adulthood (RR = 2.13, 95%CI (1.02–4.48)). This association became insignificant for all obesity phenotypes after adjusting for adulthood BMI.ConclusionAdulthood CIMT has an increasing trend based on childhood and adolescence obesity phenotypes from MHNW to MUO. Children with MUO phenotype was the only ones that had an increased risk of high CIMT incidence in early adulthood. |
| Keywords: | Obesity metabolically benign Child Carotid intima-media thickness Metabolic syndrome Obesity CIMT"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"Carotid Intima-Media Thickness BMI"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"body mass index MHNW"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"metabolically healthy normal weight MUNW"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"metabolically unhealthy normal weight MHO"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"metabolically healthy obese MUO"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"metabolically unhealthy obese Mets"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"Metabolic Syndrome FPG"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"Fasting plasma glucose WC"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"waist circumference LCCA"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"left common carotid artery far wall measurements ICC"} {"#name":"keyword" "$":{"id":"kwrd0145"} "$$":[{"#name":"text" "_":"interclass correlation coefficient OR"} {"#name":"keyword" "$":{"id":"kwrd0155"} "$$":[{"#name":"text" "_":"odds ratio |
| 本文献已被 ScienceDirect 等数据库收录！ | |