Association of the ApoB/ApoA-I ratio with stroke risk: Findings from the China Health and Nutrition Survey (CHNS) |
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| Institution: | 1. School of Public Health, Medical College of Soochow University, Suzhou, China;2. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China;1. Cardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, National and Kapodistrian University of Athens, Greece;2. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Greece;3. Department of Food Science and Human Nutrition, Agricultural University of Athens, Greece;4. Hellenic Foundation for Cardiovascular Health and Nutrition, Athens, Greece;5. 1st Department of Propaedeutic and Internal Medicine & Joint Rheumatology Program, National and Kapodistrian University of Athens, Medical School, Greece;1. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran;2. Imaging Department, Taleghani Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran;3. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran;4. Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran;1. Unit of Cardiovascular Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy;2. Unit of Food Science and Nutrition, Department of Science and Technology for Humans and the Environment, Campus Bio-Medico University of Rome, Rome, Italy;1. Department of Community Medicine, ESIC Medical College and PGIMSR, K.K. Nagar, Chennai, India;2. Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India;3. Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India;1. Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, São Paulo, Brazil;2. Department of Physical Education, State University of Maringa, Maringa, Brazil;3. Department of Physical Education, University of Parana, Curitiba, Brazil;4. Federal Institute of Education, Science and Technology of São Paulo, Hortolandia Campus, Hortolandia, Brazil |
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| Abstract: | Background and aimsStudies on associations of apolipoprotein B (ApoB), apolipoprotein A-I (ApoA-I) and the ApoB/ApoA-I ratio with stroke risk are scarce. We aimed to prospectively examine the associations of the ApoB/ApoA-I ratio and other lipid profiles with the risk of stroke using data from the China Health and Nutrition Survey (CHNS).Methods and resultsA total of 7318 participants without stroke at baseline in 2009 were included in the final analysis and followed for a median of 6.1 years. The serum lipid profiles including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), ApoA-I, and ApoB were measured at baseline. Multivariable Cox proportional hazards models were used to evaluate the associations between these parameters and stroke risk. The ApoB/ApoA-I ratio was positively associated with incident stroke, yielding adjusted hazard ratio (HR) of 1.32 (95% CI: 1.09–1.59, P = 0.004). In comparison, ratio of ApoB and ApoA-I containing lipoproteins, the non-HDL-C/HDL-C ratio, possessed relatively weaker association with incident stroke (HR: 1.24, 95% CI: 1.01–1.52, P = 0.036). Furthermore, the risk associations for the ApoB/ApoA-I and non-HDL-C/HDL-C ratios were prominent among those participants aged >51, body mass index ≤23, or female. There were no significant associations of other lipids and their ratios with the stroke risk.ConclusionsHigher ApoB/ApoA-I ratio was associated with an increased risk of stroke. Our findings suggest that the ApoB/ApoA-I ratio may serve as a better risk indicator of stroke than other lipid profiles and their ratios. |
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| Keywords: | The ApoB/ApoA-I ratio Stroke China Health and Nutrition Survey (CHNS) Longitudinal study |
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