Association between statin adherence and the risk of stroke among South Korean adults with hyperlipidemia |
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| Institution: | 1. Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea;2. Institute of Health Services Research, Yonsei University, Seoul, Republic of Korea;3. Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea;4. Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea |
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| Abstract: | Background and aimsThe effectiveness of statins commonly used to prevent stroke may depend on adherence to treatment. We examined the association between statin adherence and stroke risk among South Korean adults with hyperlipidemia.Methods and resultsThe data of 128,052 and 129,390 participants with hyperlipidemia for the purpose of studying the risks of ischemic and hemorrhagic stroke, respectively, were collected from the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2013. Participants were divided into groups according to statin adherence, calculated as the proportion of days covered (PDC; poor, moderate, good). The risk of ischemic and hemorrhagic stroke were analyzed using a Cox proportional hazards model. Individuals with poor PDC exhibited higher risks of ischemic and hemorrhagic stroke than those with good PDC (ischemic stroke: hazard ratio HR] = 1.09, 95% confidence interval CI] = 1.03–1.15, hemorrhagic stroke: HR = 1.37, 95% CI = 1.22–1.54). Women with poor PDC were at higher risk of ischemic stroke than those with good PDC (HR = 1.17, 95% CI = 1.09–1.26), while men with poor PDC exhibited a higher risk of hemorrhagic stroke than those with good PDC (HR = 1.55, 95% CI = 1.27–1.90). Individuals with disabilities who had poor PDC were at higher risk of ischemic stroke than those with good PDC (HR = 1.55, 95% CI = 1.24–1.93).ConclusionsWe detected a significant association between statin adherence and ischemic and hemorrhagic stroke risk. Therefore, hyperlipidemia patients should adhere to statin treatment; such interventions are required to reduce the stroke risk. |
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| Keywords: | Ischemic stroke Hemorrhagic stroke Statin adherence Hyperlipidemia Usual provider continuity index Proportion of days covered CCI"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"Charlson comorbidity index CI"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"Confidence interval COC"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"Continuity of care CVD"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"Cardiovascular disease HR"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"Hazard ratio PDC"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"Proportion of days covered UPC"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"Usual provider continuity |
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