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Evolution of Gene Therapy,Historical Perspective
Institution:1. Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC1456, Bldg 10, Rm 5-3750, Bethesda, MD 20892-1456, USA;2. National Human Genome Research Institute, NIH, 10 Center Dr, MSC1611, Bldg 10, Rm 10C-103, Bethesda, MD 20892-1611, USA;3. National Heart, Lung, and Blood Institute, NIH, 10 Center Drive, MSC1812, Bldg 10, Rm 9N119, Bethesda, MD 20892-1812, USA;1. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21287, USA;2. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA;1. Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children''s Research Hospital, 262 Danny Thomas Place, MS1130, Memphis, TN 38105, USA;2. Division of Oncology, Children''s Hospital of Philadelphia, Office 2568A, 3500 Civic Center Blvd, Philadelphia, PA 19104, USA;3. Seattle Children''s Research Institute, 4800 Sand Point Way NE, M/S MB8.501, Seattle, WA 98145-5005, USA;4. Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1W-5750, 9000 Rockville Pike, Bethesda, MD 20892-1104, USA;1. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;2. Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, NY;3. Kadmon Research Institute, New York, NY;4. CNR-IRGB, Milan Unit, Milan, Italy;5. Humanitas Clinical and Research Center, Rozzano, Milan, Italy;6. Department of Pathology, University of Brescia, Brescia, Italy;7. Telethon Institute for Gene Therapy–H San Raffaele, Milan, Italy;8. Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands;1. Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Str.1, Hannover 30625, Germany;2. REBIRTH Research Center for Translational Regenerative Medicine, Hannover Medical School, Carl-Neuberg-Str.1, Hannover 30625, Germany;3. German Center for Infection Research, Partner Site Hannover-Braunschweig;1. Johns Hopkins School of Medicine, Baltimore, Maryland;2. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland;3. Children’s National Medical Center, Washington, D.C.;4. David Geffen School of Medicine, University of California, Los Angeles, California;5. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Abstract:
Keywords:Gamma retrovirus vector  Lentiviral vector  Gene editing  Hematopoietic stem cells  Transduction  Apheresis  CD34+ HSC  Insertional mutagenesis
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