| 抗轮状病毒牛初乳抑制肠道轮状病毒的机制探讨 |
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| 引用本文： | 郁凯明,徐猗.抗轮状病毒牛初乳抑制肠道轮状病毒的机制探讨[J].临床儿科杂志,1998,16(4):253-255. |
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| 作者姓名： | 郁凯明 徐猗 |
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| 作者单位： | [1]上海第二医科大学 [2]上海第二医科大学附属新华医院小儿传染科 |
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| 摘 要： | 本文应用抗轮状病毒免疫牛初乳，对４３例轮状病毒感染性腹泻患儿进行了治疗，同时对３７例轮状病毒感染性腹泻患儿给予思密达治疗作了对照，以观察两组的治疗效果与大便排毒之间的关系。结果免疫初乳治疗组７２小时止泻的总有效率为９１％，大便病毒抗原转阴率为８９％；而思密达组总有效率为４１％，经治疗７２小时腹泻仍不止２２例，占５９％，７２小时大便病毒抗原仍阳性为６１％。表明抗轮状病毒免疫牛初乳能有效地发挥其特异性
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| 关 键 词： | 初乳 轮状病毒 腹泻 儿童 抗病毒作用 牛乳 |
Exploration of mechanism of bovine colostrum specific antibody for lahibiting rotavirus in intestinal tract |
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| Yu Kai-ming,Xu Yi,Huang Hai,Jiang Ming-hua.Exploration of mechanism of bovine colostrum specific antibody for lahibiting rotavirus in intestinal tract[J].The Journal of Clinical Pediatrics,1998,16(4):253-255. |
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| Authors: | Yu Kai-ming Xu Yi Huang Hai Jiang Ming-hua |
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| Institution: | Yu Kai-ming,Xu Yi,Huang Hai,Jiang Ming-hua. Shanghai Institute for Pediatric Research,Shanghai Second Medical University,Shanghai 200092 |
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| Abstract: | Forty-three infants with rotavirus infectious diarrhea were treated with cow colostrum containing antibody against human rotavirus. Thirty-seven infants suffering from rotavirus infectious diarrhea as control group theraputed by smecta. The comparison for relationship between efficiency of antidiarrhea and viral excreting in stool was made in two groups. The results showed that the total therapeutic efficiency is 91 % and viral antigen in stool couldn't be detected in 89% after treatment in colostrum group. But the total treating efficiency is only 41% and positive rate of viral antigen in stool was 61% after administration of drug in the group of smecta therapy. It demonstrated that antirotaviral colostrum could specifically neutralize virus and inhibit viral multiplication in intestinal tract, and therefore exert the effect of then-py; while smecta only play a role of protective barrier for intestinal mucosa without specific antiviral effect. |
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| Keywords: | colostrum rotavirus diarrhea Smecta |
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